Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review.
Pharmacologic agents to promote mucus clearance may reduce the sequelae of obstructive secretions. We systematically reviewed comparative studies of pharmacologic agents for mucus clearance in hospitalized or postoperative subjects without cystic fibrosis and over 12 months of age. We searched MEDLI...
| Publicado en: | Respiratory Care Vol. 60; no. 7; pp. 1061 - 1071 |
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| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109828120&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109828120 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Jul2015 vid: 60 iid: 7 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 109828120 108375785 10.4187/respcare.04086 109828120 ppf: 1061 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review. aug: au: Sathe, Nila A. Krishnaswami, Shanthi Andrews, Jeff Ficzere, Cathy McPheeters, Melissa L. affil: Vanderbilt Evidence-based Practice Center, Institute for Medicine and Public Health; Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee sug: subj: Airway Management Inpatients Mucus Drug Effects Mucociliary Clearance Expectorants Therapeutic Use Human Systematic Review Medline Acetylcysteine Therapeutic Use Heparin Therapeutic Use Albuterol Therapeutic Use Ipratropium Therapeutic Use Aged Adult Middle Age Aged, 80 and Over Child, Preschool Child Adolescence Male Female Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Aged, 80 & over Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Pharmacologic agents to promote mucus clearance may reduce the sequelae of obstructive secretions. We systematically reviewed comparative studies of pharmacologic agents for mucus clearance in hospitalized or postoperative subjects without cystic fibrosis and over 12 months of age. We searched MEDLINE and other databases from January 1970 to July 2014 to identify relevant literature. Two reviewers independently assessed each study against predetermined inclusion/exclusion criteria. Two reviewers also independently extracted data regarding subject and intervention characteristics and outcomes and assigned overall quality ratings. The 9 studies meeting review criteria included 5 randomized controlled trials, 3 crossover randomized controlled trials, and one retrospective cohort study. Studies were small and together included a total of 379 subjects (mean of 42 subjects per study). N-acetylcysteine, heparin plus N-acetylcysteine, albuterol, ipratropium bromide, and saline were assessed. Studies reported no benefit of studied agents on expectoration, pulmonary function, and atelectasis and little effect on changes in sputum volume, weight, or viscosity. Adverse effects of agents were not consistently reported. Nausea was reported in 2 studies of N-acetylcysteine (one paper reported 2 experiments and did not clearly identify in which experiment adverse effects occurred), 3 studies reported that there were no adverse events, and 3 studies did not address adverse effects at all. Further research with clearly characterized populations and interventions is needed to understand the potential benefits and adverse effects of mucoactive agents. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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