Lateral preference in Williams-Beuren syndrome is associated with cognition and language.
Williams-Beuren syndrome (WBS) is a genetically defined neurodevelopmental disorder presenting with intellectual disability associated with a specific neurocognitive profile characterized by anxiety, hypersociability, poor visuospatial skills and relatively preserved language. We have defined the la...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 24; no. 9; pp. 1025 - 1034 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109838553&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109838553 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2015 vid: 24 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 109838553 109189377 10.1007/s00787-014-0652-6 NLM25431039 109838553 ppf: 1025 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Lateral preference in Williams-Beuren syndrome is associated with cognition and language. aug: au: Pérez-García, D. Flores, R. Brun-Gasca, C. Pérez-Jurado, L. affil: Department of Clinical Psychology and Health Psychology, Universitat Autònoma de Barcelona, 08193 Bellatera, Barcelona Spain sug: subj: Williams Syndrome Psychosocial Factors Dominance, Cerebral Psychosocial Factors Cognition Language Human Male Female Descriptive Statistics Data Analysis Software Confidence Intervals Odds Ratio Narratives Books Child Behavior Checklist Scales Checklists Analysis of Variance Mann-Whitney U Test Funding Source Male Female ab: Williams-Beuren syndrome (WBS) is a genetically defined neurodevelopmental disorder presenting with intellectual disability associated with a specific neurocognitive profile characterized by anxiety, hypersociability, poor visuospatial skills and relatively preserved language. We have defined the lateral preference in 69 individuals (40 males and 29 females, age range 5-47 years) with WBS confirmed by molecular testing, and explored its correlation with cognition, behavior problems, the main aspects of the behavioral phenotype, and specific molecular variants (parental origin and size of the 7q11.23 deletion). Lateral preference (hand, foot, eye and ear) and neurobehavioral features [intelligence quotient (IQ), sociability, visuospatial construction, narrative skills and behavior] were assessed by a battery of tests and parental interviews. A large proportion of WBS individuals showed either left or mixed handedness (26 and 19 %, respectively). Hand, foot and ear lateral preference showed significant association with IQ, with individuals with mixed lateral preference presenting lower general IQ, especially verbal IQ, with respect to subjects with well-defined laterality. Approachability, visuospatial ability, behavior problems or molecular variants were not associated with lateral preference. Our results indicate that, as in other neurodevelopmental disorders, laterality is poorly defined in a significant proportion of WBS individuals, and reinforces the idea that a correct definition of lateral preference is important for cognition and language. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|