Design expert supported mathematical optimization and predictability study of buccoadhesive pharmaceutical wafers of loratadine.
Objective. The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine (LOR). Methods. Experiments were performed according to a 3² factorial design to evaluate the effects of buccoadhesive polymer, s...
| Publicado en: | BioMed Research International Vol. 2013; pp. 197398 - 197399 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109858330&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109858330 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 109858330 2012159777 10.1155/2013/197398 NLM23781498 PMC3679693 109858330 ppf: 197398 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Design expert supported mathematical optimization and predictability study of buccoadhesive pharmaceutical wafers of loratadine. aug: au: Chakraborty, Prithviraj Dey, Surajit Parcha, Versha Bhattacharya, Shiv Sankar Ghosh, Amitava affil: Bengal College of Pharmaceutical Sciences and Research, West Bengal University of Technology, B.R.B. Sarani, Durgapur, West Bengal 713212, India. sug: subj: Adhesives Pharmacodynamics Dosage Forms Loratadine Administration and Dosage Loratadine Pharmacodynamics Models, Theoretical Administration, Buccal Analysis of Variance Animal Studies Calorimetry Cattle Chemistry, Pharmaceutical Drug Delivery Systems In Vitro Studies Pilot Studies Spectrophotometry, Infrared Time Factors X-Rays ab: Objective. The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine (LOR). Methods. Experiments were performed according to a 3² factorial design to evaluate the effects of buccoadhesive polymer, sodium alginate (A), and lactose monohydrate as ingredient, of hydrophilic matrix former (B) on the bioadhesive force, disintegration time, percent (%) swelling index, and time taken for 70% drug release (t70%). The effect of the two independent variables on the response variables was studied by response surface plots and contour plots generated by the Design-Expert software. The desirability function was used to optimize the response variables. Results. The compatibility between LOR and the wafer excipients was confirmed by differential scanning calorimetry, FTIR spectroscopy, and X-ray diffraction (XRD) analysis. Bioadhesion force, measured with TAXT2i texture analyzer, showed that the wafers had a good bioadhesive property which could be advantageous for retaining the drug into the buccal cavity. Conclusion. The observed responses taken were in agreement with the experimental values, and Loratadine wafers were produced with less experimental trials, and a patient compliant product was achieved with the concept of formulation by design. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|