Home Circadian Phase Assessments with Measures of Compliance Yield Accurate Dim Light Melatonin Onsets.
STUDY OBJECTIVES: There is a need for the accurate assessment of circadian phase outside of the clinic/laboratory, particularly with the gold standard dim light melatonin onset (DLMO). We tested a novel kit designed to assist in saliva sampling at home for later determination of the DLMO. The home k...
| Publicado en: | Sleep Vol. 38; no. 6; pp. 889 - 898 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109881234&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109881234 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01618105 2EI jtl: Sleep issn: 01618105 maglogo: N pubinfo: dt: 2015 vid: 38 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 109881234 2013041186 10.5665/sleep.4734 NLM25409110 PMC4434555 109881234 ppf: 889 ppct: 9 formats: tig: atl: Home Circadian Phase Assessments with Measures of Compliance Yield Accurate Dim Light Melatonin Onsets. aug: au: Burgess, Helen J Wyatt, James K Park, Margaret Fogg, Louis F sug: ab: STUDY OBJECTIVES: There is a need for the accurate assessment of circadian phase outside of the clinic/laboratory, particularly with the gold standard dim light melatonin onset (DLMO). We tested a novel kit designed to assist in saliva sampling at home for later determination of the DLMO. The home kit includes objective measures of compliance to the requirements for dim light and half-hourly saliva sampling. DESIGN: Participants were randomized to one of two 10-day protocols. Each protocol consisted of two back-to-back home and laboratory phase assessments in counterbalanced order, separated by a 5-day break. SETTING: Laboratory or participants' homes. PARTICIPANTS: Thirty-five healthy adults, age 21-62 y. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Most participants received at least one 30-sec epoch of light > 50 lux during the home phase assessments (average light intensity 4.5 lux), but on average for < 9 min of the required 8.5 h. Most participants collected every saliva sample within 5 min of the scheduled time. Ninety-two percent of home DLMOs were not affected by light > 50 lux or sampling errors. There was no significant difference between the home and laboratory DLMOs (P > 0.05); on average the home DLMOs occurred 9.6 min before the laboratory DLMOs. The home DLMOs were highly correlated with the laboratory DLMOs (r = 0.91, P < 0.001). CONCLUSIONS: Participants were reasonably compliant to the home phase assessment procedures. The good agreement between the home and laboratory dim light melatonin onsets (DLMOs) demonstrates that including objective measures of light exposure and sample timing during home saliva sampling can lead to accurate home DLMOs. CLINICAL TRIAL REGISTRATION: Circadian Phase Assessments at Home, http://clinicaltrials.gov/show/NCT01487252, NCT01487252. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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