Mismatch negativity (MMN) reveals inefficient auditory ventral stream function in chronic auditory comprehension impairments.
BACKGROUND: Auditory discrimination is significantly impaired in Wernicke's aphasia (WA) and thought to be causatively related to the language comprehension impairment which characterises the condition. This study used mismatch negativity (MMN) to investigate the neural responses corresponding to su...
| Publicado en: | Cortex: A Journal Devoted to the Study of the Nervous System & Behavior Vol. 59; pp. 113 - 126 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Masson SPA
2014 Oct
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109881517&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109881517 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00109452 GMP jtl: Cortex: A Journal Devoted to the Study of the Nervous System & Behavior issn: 00109452 maglogo: N pubinfo: dt: 2014 Oct vid: 59 pid: 12473 pub: Masson SPA artinfo: ui: 109881517 109881517 2012799958 10.1016/j.cortex.2014.07.009 NLM25173955 109881517 ppf: 113 ppct: 13 formats: tig: atl: Mismatch negativity (MMN) reveals inefficient auditory ventral stream function in chronic auditory comprehension impairments. aug: au: Robson, Holly Cloutman, Lauren Keidel, James L Sage, Karen Drakesmith, Mark Welbourne, Stephen sug: subj: Aphasia, Wernicke Physiopathology Neural Pathways Physiopathology Auditory Perception Physiology Cerebral Cortex Physiopathology Readability Evoked Potentials, Auditory Physiology Acoustic Stimulation Aged Auditory Threshold Electroencephalography Human Male Neuropsychological Tests Reaction Time Physiology Aged: 65+ years Male ab: BACKGROUND: Auditory discrimination is significantly impaired in Wernicke's aphasia (WA) and thought to be causatively related to the language comprehension impairment which characterises the condition. This study used mismatch negativity (MMN) to investigate the neural responses corresponding to successful and impaired auditory discrimination in WA. METHODS: Behavioural auditory discrimination thresholds of consonant-vowel-consonant (CVC) syllables and pure tones (PTs) were measured in WA (n = 7) and control (n = 7) participants. Threshold results were used to develop multiple deviant MMN oddball paradigms containing deviants which were either perceptibly or non-perceptibly different from the standard stimuli. MMN analysis investigated differences associated with group, condition and perceptibility as well as the relationship between MMN responses and comprehension (within which behavioural auditory discrimination profiles were examined). RESULTS: MMN waveforms were observable to both perceptible and non-perceptible auditory changes. Perceptibility was only distinguished by MMN amplitude in the PT condition. The WA group could be distinguished from controls by an increase in MMN response latency to CVC stimuli change. Correlation analyses displayed a relationship between behavioural CVC discrimination and MMN amplitude in the control group, where greater amplitude corresponded to better discrimination. The WA group displayed the inverse effect; both discrimination accuracy and auditory comprehension scores were reduced with increased MMN amplitude. In the WA group, a further correlation was observed between the lateralisation of MMN response and CVC discrimination accuracy; the greater the bilateral involvement the better the discrimination accuracy. CONCLUSIONS: The results from this study provide further evidence for the nature of auditory comprehension impairment in WA and indicate that the auditory discrimination deficit is grounded in a reduced ability to engage in efficient hierarchical processing and the construction of invariant auditory objects. Correlation results suggest that people with chronic WA may rely on an inefficient, noisy right hemisphere auditory stream when attempting to process speech stimuli. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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