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Cluster of Cryptococcus neoformans Infections in Intensive Care Unit, Arkansas, USA, 2013.

We investigated an unusual cluster of 6 patients with Cryptococcus neoformans infection at a community hospital in Arkansas during April-December 2013, to determine source of infection. Four patients had bloodstream infection and 2 had respiratory infection; 3 infections occurred within a 10-day per...

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Published in:Emerging Infectious Diseases pp. 1719 - 1725
Main Authors: Vallabhaneni, Snigdha, Haselow, Dirk, Lloyd, Spencer, Lockhart, Shawn, Moulton-Meissner, Heather, Lester, Laura, Wheeler, Gary, Gladden, Linda, Garner, Kelley, Derado, Gordana, Park, Benjamin, Harris, Julie R.
Format: research tables/charts Journal Article
Published: Centers for Disease Control & Prevention (CDC) Oct2015
Online Access:View this record in EBSCOhost
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      dt: Oct2015
      pid: 1493
      pub: Centers for Disease Control & Prevention (CDC)
      place: Atlanta, Georgia
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        atl: Cluster of Cryptococcus neoformans Infections in Intensive Care Unit, Arkansas, USA, 2013.
      aug:
        au:
          Vallabhaneni, Snigdha
          Haselow, Dirk
          Lloyd, Spencer
          Lockhart, Shawn
          Moulton-Meissner, Heather
          Lester, Laura
          Wheeler, Gary
          Gladden, Linda
          Garner, Kelley
          Derado, Gordana
          Park, Benjamin
          Harris, Julie R.
        affil: Centers for Disease Control and Prevention, Atlanta, Georgia, USA
      sug:
        subj:
          Education, Medical, Continuing
          Cryptococcosis Transmission
          Cryptococcus
          Prospective Studies
          Hospitals, Community
          Human
          Cryptococcosis Pathology
          Retrospective Design
          Cryptococcosis
          Intensive Care Units
          Arkansas
      ab: We investigated an unusual cluster of 6 patients with Cryptococcus neoformans infection at a community hospital in Arkansas during April-December 2013, to determine source of infection. Four patients had bloodstream infection and 2 had respiratory infection; 3 infections occurred within a 10-day period. Five patients had been admitted to the intensive care unit (ICU) with diagnoses other than cryptococcosis; none had HIV infection, and 1 patient had a history of organ transplantation. We then conducted a retrospective cohort study of all patients admitted to the ICU during April-December 2013 to determine risk factors for cryptococcosis. Four patients with C. neoformans infection had received a short course of steroids; this short-term use was associated with increased risk for cryptococcosis (rate ratio 19.1; 95% CI 2.1-170.0; p<0.01). Although long-term use of steroids is a known risk factor for cryptococcosis, the relationship between short-term steroid use and disease warrants further study.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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