Gout is not associated with a lower risk of Parkinson's disease: A systematic review and meta-analysis.
Background: Uratic acid is a potent anti-oxidant and hyperuricemia is well-linked to a lower risk of Parkinson's disease (PD), one of the most common neurodegenerative disorders. However, data on gout, the major complication of hyperuricemia, remain unclear.Methods: Two investigators independently s...
| Publicado en: | Parkinsonism & Related Disorders Vol. 21; no. 10; pp. 1238 - 1243 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=109955958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 109955958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13538020 JNO jtl: Parkinsonism & Related Disorders issn: 13538020 maglogo: N pubinfo: dt: Oct2015 vid: 21 iid: 10 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 109955958 109955958 NLM26330027 10.1016/j.parkreldis.2015.08.030 NLM26330027 109955958 ppf: 1238 ppct: 5 formats: tig: atl: Gout is not associated with a lower risk of Parkinson's disease: A systematic review and meta-analysis. aug: au: Ungprasert, Patompong Srivali, Narat Thongprayoon, Charat affil: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA sug: ab: Background: Uratic acid is a potent anti-oxidant and hyperuricemia is well-linked to a lower risk of Parkinson's disease (PD), one of the most common neurodegenerative disorders. However, data on gout, the major complication of hyperuricemia, remain unclear.Methods: Two investigators independently searched published studies indexed in MEDLINE, and EMBASE from inception to April 2015 using the terms for gout combined with the terms for PD. The inclusion criteria were as follows: (1) cohort or case-control study evaluating the risk of PD among patients with gout (2) odds ratio, relative risk, hazard ratio or standardized incidence ratio were provided (3) subjects without gout and subjects with PD were used as controls in cohort and case-control study, respectively. RevMan 5.3 software was used to perform the statistical analysis. Point estimates and standard errors were extracted from individual studies and were combined by generic inverse variance method of DerSimonian and Laird. Statistical heterogeneity was assessed using the Cochran's Q test and I(2) statistics.Results: Three case-control studies and two cohort studies were identified and included in the data analysis. The pooled risk ratio of PD in patients with gout was 0.93 (95% CI, 0.79 to 1.09). The statistical heterogeneity was high with an I(2) of 87%. The results were not significantly different between males and females (RR 0.89; 95% CI, 0.57 to 1.39 and RR 0.95; 95% CI, 0.76 to 1.19, respectively).Conclusion: This study did not provide support for an inverse relationship between gout and risk of PD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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