Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients.
Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper...
| Publicado en: | Internal & Emergency Medicine Vol. 10; no. 7; pp. 787 - 795 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110068374&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110068374 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18280447 46A5 jtl: Internal & Emergency Medicine issn: 18280447 maglogo: N pubinfo: dt: Oct2015 vid: 10 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 110068374 110068374 NLM25739590 110068374 10.1007/s11739-015-1218-4 NLM25739590 110068374 ppf: 787 ppct: 8 formats: tig: atl: Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients. aug: au: Dore, Maria Marras, Giuseppina Rocchi, Chiara Soro, Sara Loria, Maria Bassotti, Gabrio Graham, David Malaty, Hoda Pes, Giovanni Dore, Maria Pina Loria, Maria Francesca Graham, David Y Malaty, Hoda M Pes, Giovanni M affil: Dipartimento di Medicina Clinica e Sperimentale, Clinica Medica, University of Sassari, Viale San Pietro, 8 07100 Sassari Italy sug: subj: Helicobacter Infections Drug Therapy Dyspepsia Therapy Peptic Ulcer Drug Therapy Aged, 80 and Over Prevalence Middle Age Female Helicobacter Pylori Male Adult Helicobacter Infections Epidemiology Retrospective Design Aged Human Dyspepsia Epidemiology Helicobacter Pylori Drug Effects Italy Peptic Ulcer Epidemiology Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspepsia. A retrospective observational study was conducted involving patients undergoing endoscopy for dyspepsia from 1995 to 2013. H. pylori status was assessed by histology plus the rapid urease test or 13C-UBT. Gastric mucosal lesions were evaluated histologically. Data including non-steroidal anti-inflammatory drugs (NSAIDs) use and the presence of peptic ulcers were collected. The prevalence of H. pylori was calculated for each quartile and for each birth cohort from 1910 to 2000. 11,202 records were retrieved for the analysis (62.9% women). The overall prevalence of H. pylori infection was 43.8% (M: 46.6% vs. F: 42.0%; P = 0.0001). A dramatic decrease in the prevalence of infection occurred over the 19-year observation period. The birth cohort effect was evident in each category (quartile) reflecting the continuous decline in H. pylori acquisition. Over time, the prevalence of peptic ulcers also declined, resulting in an increase in the proportion of H. pylori negative/NSAID positive and H. pylori negative/NSAID negative peptic ulcers. The prevalence of gastric mucosal changes also declined despite aging. The decline in H. pylori prevalence over time likely reflects the improvement in socioeconomic conditions in Sardinia such that H. pylori infection and its clinical outcomes including peptic ulcer are becoming less frequent even among dyspeptic patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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