Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma.
There are no previous studies of the association between prediagnostic serum vitamin D concentration and glioma. Vitamin D has immunosuppressive properties; as does glioma. It was, therefore, our hypothesis that elevated vitamin D concentration would increase glioma risk. We conducted a nested case-...
| Publicado en: | Nutrition & Cancer Vol. 67; no. 7; pp. 1120 - 1131 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110072097&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110072097 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Oct2015 vid: 67 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 110072097 110072097 110072097 10.1080/01635581.2015.1073757 NLM26317248 110072097 ppf: 1120 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma. aug: au: Zigmont, Victoria Garrett, Amy Peng, Jin Seweryn, Michal Rempala, Grzegorz A. Harris, Randall Holloman, Christopher Gundersen, Thomas E. Ahlbom, Anders Feychting, Maria Johannesen, Tom Borge Grimsrud, Tom Kristian Schwartzbaum, Judith affil: Comprehensive Cancer Center and Division of Epidemiology, College of Public Health, Ohio State University, Columbus, Ohio, USA sug: subj: Glioma Diagnosis Vitamin D Blood Nutrition Human Vitamin D Physiology Glioma Prevention and Control Registries, Disease Data Analysis Glioma Classification Odds Ratio Confidence Intervals Blood Chemical Analysis Funding Source ab: There are no previous studies of the association between prediagnostic serum vitamin D concentration and glioma. Vitamin D has immunosuppressive properties; as does glioma. It was, therefore, our hypothesis that elevated vitamin D concentration would increase glioma risk. We conducted a nested case-control study using specimens from the Janus Serum Bank cohort in Norway. Blood donors who were subsequently diagnosed with glioma (n= 592), between 1974 and 2007, were matched to donors without glioma (n= 1112) on date and age at blood collection and sex. We measured 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D availability, using liquid chromatography coupled with mass spectrometry. Seasonally adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for each control quintile of 25(OH)D using conditional logistic regression. Among men diagnosed with high grade glioma >56, we found a negative trend (P= .04). Men diagnosed ≤ 56 showed a borderline positive trend (P= .08). High levels (>66 nmol/L) of 25(OH)D in men >56 were inversely related to high grade glioma from ≥2 yr before diagnosis (OR = 0.59; 95% CI = 0.38, 0.91) to ≥15 yr before diagnosis (OR = 0.61; 95% CI = 0.38,0.96). Our findings are consistent long before glioma diagnosis and are therefore unlikely to reflect preclinical disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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