Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.
To investigate the biological foundation of the inflammatory bowel disease (IBD), ulcerative colitis and Crohn's disease, susceptibility locus rs2872507, we have investigated the expression of 13 genes using ileal and colonic biopsies from patients with IBD (inflamed and noninflamed mucosa) or from...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 11 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
9/21/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110155491&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110155491 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 9/21/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 110155491 110155491 NLM26484354 110155491 10.1155/2015/834805 NLM26484354 PMC4592899 110155491 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility. aug: au: Söderman, Jan Berglind, Linda Almer, Sven affil: Division of Medical Diagnostics, Ryhov County Hospital, 55185 Jönköping, Sweden sug: subj: Gene Expression Genotype Inflammatory Bowel Diseases Risk Factors Human Male Female Adolescence Adult Middle Age Aged Descriptive Statistics Data Analysis Software Odds Ratio Confidence Intervals Endoscopy Inflammation Genetics Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: To investigate the biological foundation of the inflammatory bowel disease (IBD), ulcerative colitis and Crohn's disease, susceptibility locus rs2872507, we have investigated the expression of 13 genes using ileal and colonic biopsies from patients with IBD (inflamed and noninflamed mucosa) or from individuals without IBD (noninflamed mucosa). The susceptibility allele was consistently associated with reduced expression of GSDMB (P = 4.1 × 10(-3)-7.2 × 10(-10)). The susceptibility allele was also associated with the increased expression of GSDMA (P = 1.6 × 10(-4)) and LRRC3C (P = 7.8 × 10(-6)) in colon tissue from individuals without IBD and with the reduced expression of PGAP3 (IBD; P = 2.0 × 10(-3)) and ZPBP2 (Crohn's disease; P = 7.7 × 10(-4)) in noninflamed ileum. Inflammation resulted in the reduced colonic expression of ERBB2, GRB7, MIEN1, and PGAP3 (P = 1.0 × 10(-4)-1.0 × 10(-9)) and the increased colonic expression of IKZF3 and CSF3 (P = 2.4 × 10(-7)-3.5 × 10(-8)). Based on our results and published findings on GSDMA, GSDMB, LRRC3C, and related proteins, we propose that this locus in part affects IBD susceptibility via effects on apoptosis and cell proliferation and believe this hypothesis warrants further experimental investigation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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