Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects.
INTRODUCTION: High-flow nasal cannula (HFNC) can deliver heated and humidified gas (up to 100% oxygen) at a maximum flow of 60 L/min via nasal prongs or cannula. The aim of this study was to assess the short-term physiologic effects of HFNC. Inspiratory muscle effort, gas exchange, dyspnea score, an...
| Publicado en: | Respiratory Care Vol. 60; no. 10; pp. 1369 - 1377 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110209449&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110209449 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Oct2015 vid: 60 iid: 10 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 110209449 110209449 110209449 10.4187/respcare.03814 NLM25944940 110209449 ppf: 1369 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Physiologic Effects of High-Flow Nasal Cannula Oxygen in Critical Care Subjects. aug: au: Vargas, Frederic Saint-Leger, Mélanie Boyer, Alexandre Nam H. Bui Hilbert, Gilles affil: Service de Réanimation Médicale, Hôpital Pellegrin-Tripode, Bordeaux, France sug: subj: Critically Ill Patients Nasal Cannula Oxygen Therapy Utilization Human Continuous Positive Airway Pressure Friedman Test Wilcoxon Signed Rank Test Repeated Measures Matched-Pair Analysis Post Hoc Analysis Male Female Middle Age Aged Aged, 80 and Over Funding Source Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: INTRODUCTION: High-flow nasal cannula (HFNC) can deliver heated and humidified gas (up to 100% oxygen) at a maximum flow of 60 L/min via nasal prongs or cannula. The aim of this study was to assess the short-term physiologic effects of HFNC. Inspiratory muscle effort, gas exchange, dyspnea score, and comfort were evaluated. METHODS: Twelve subjects admitted to the ICU for acute hypoxemic respiratory failure were prospectively included. Four study sessions were performed. The first session consisted of oxygen therapy given through a high-FIO2, non-rebreathing face mask. Recordings were then obtained during periods of HFNC and CPAP at 5 cm H2O in random order, and final measurements were performed during oxygen therapy delivered via a face mask. Each of these 4 periods lasted ~20 min. RESULTS: Esophageal pressure signals, breathing pattern, gas exchange, comfort, and dyspnea were measured. Compared with the first session, HFNC reduced inspiratory effort (pressure-time product of 156.0 [119.2-194.4] cm H2O X s/min vs 204.2 [149.6-324.7] cmH2O X s/min, P < .01) and breathing frequency (P < .01). No significant differences were observed between HFNC and CPAP for inspiratory effort and breathing frequency. Compared with the first session, PaO2/FIO2 increased significantly with HFNC (167 [157-184] mm Hg vs 156 [110-171] mm Hg, P < .01). CPAP produced significantly greater PaO2/FIO2 improvement than did HFNC. Dyspnea improved with HFNC and CPAP, but this improvement was not significant. Subject comfort was not different across the 4 sessions. CONCLUSIONS: Compared with conventional oxygen therapy, HFNC improved inspiratory effort and oxygenation. In subjects with acute hypoxemic respiratory failure, HFNC is an alternative to conventional oxygen therapy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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