Biomonitoring for Exposure Assessment to Styrene in the Fibreglass Reinforced Plastic Industry: Determinants and Interferents.
Fifty-eight workers exposed to styrene were monitored in four fibreglass reinforced plastic industries of Central Italy. The aim of the study was to explore the factors that can influence the levels of styrene exposure biomarkers of the workers and the aspects that might interfere with the exposure...
| Publicado en: | Annals of Occupational Hygiene Vol. 59; no. 8; pp. 1000 - 1012 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Oct2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110338487&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110338487 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00034878 JQ4 jtl: Annals of Occupational Hygiene issn: 00034878 maglogo: N pubinfo: dt: Oct2015 vid: 59 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 110338487 110338487 110338487 10.1093/annhyg/mev047 NLM26180262 110338487 ppf: 1000 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Biomonitoring for Exposure Assessment to Styrene in the Fibreglass Reinforced Plastic Industry: Determinants and Interferents. aug: au: Bonanni, Rossana Claudia Gatto, Maria Pia Paci, Enrico Gordiani, Andrea Gherardi, Monica Tranfo, Giovanna affil: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Monte Porzio Catone 00040, Rome, Italy sug: subj: Environmental Monitoring Occupational Exposure Evaluation Air Pollutants, Occupational Analysis Plastics Manufacturing Industry Italy Italy Solvents Creatinine Gas Chromatography-Mass Spectrometry Chromatography, High Pressure Liquid Multiple Regression Linear Regression Respiratory Protective Devices Air Pollutants, Occupational Blood Saliva Human Benzylidene Compounds Urine Benzylidene Compounds Blood ab: Fifty-eight workers exposed to styrene were monitored in four fibreglass reinforced plastic industries of Central Italy. The aim of the study was to explore the factors that can influence the levels of styrene exposure biomarkers of the workers and the aspects that might interfere with the exposure assessment measures, such as the co-exposure to acetone. Personal monitoring of professional exposure to airborne styrene and acetone was carried out by Radiello® samplers and GC/MS analysis. Biological monitoring was performed by the determination of urinary metabolites, mandelic (MA), and phenylglyoxylic (PGA) acids with HPLC/ MS/MS and unmetabolized styrene in saliva and venous blood by HS/GC/MS. The median values of the four sites ranged between 24.1 to 94.0 mg m-3 and 7.3 to 331.1 mg g-1 creatinine for airborne styrene and MA + PGA, respectively. A good linear correlation was found between styrene in air and its urinary metabolites (r = 0.854). The median value for airborne styrene was found to exceed the (Threshold Limit Value - Time Weighted Average) of 85 mg m−3 in one site for all the workers and in two if only moulders are considered. The multiple linear regression model showed that the determinants of urinary MA + PGA excretion were the type of process, workers' tasks, level of acetone co-exposure, and the use of respiratory protection devices. Data show that the simultaneous exposure to acetone modify the styrene metabolism with a reduction in the levels of (MA + PGA) excreted. A significant linear log-correlation was found between salivary levels of styrene and blood concentration (r = 0.746) sampled at the same tx time. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|