Adverse drug reactions in a primary care population prescribed non-steroidal anti-inflammatory drugs.
Objective. To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a non-serious adverse drug reaction (ADR).Design. Cohort study.Setting. A healthcare database containin...
| Publicado en: | Scandinavian Journal of Primary Health Care Vol. 33; no. 3; pp. 163 - 170 |
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| Autores principales: | , , , , , , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110360778&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110360778 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02813432 BDB jtl: Scandinavian Journal of Primary Health Care issn: 02813432 maglogo: Y pubinfo: dt: 2015 vid: 33 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 110360778 110360778 110360778 10.3109/02813432.2015.1067513 NLM26198810 110360778 ppf: 163 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Adverse drug reactions in a primary care population prescribed non-steroidal anti-inflammatory drugs. aug: au: Koffeman, Aafke R. Van Buul, Amanda R. Valkhoff, Vera E. Jong, Geert W. 'T Bindels, Patrick J. E. Sturkenboom, Miriam C.J.M. Van der Lei, Johan Luijsterburg, Pim A.J. Bierma-Zeinstra, Sita M.A. affil: Department of General Practice, Erasmus University Medical Center, Rotterdam, The Netherlands sug: subj: Antiinflammatory Agents, Non-Steroidal Adverse Effects Musculoskeletal Diseases Drug Therapy Prospective Studies Record Review Netherlands Adult Human Dyspepsia Chemically Induced Diarrhea Chemically Induced Dyspnea Chemically Induced Male Female Adult: 19-44 years Male Female ab: Objective. To determine how often patients with musculoskeletal (MSK) complaints prescribed a non-steroidal anti-inflammatory drug (NSAID) subsequently consult their general practitioner (GP) with a non-serious adverse drug reaction (ADR).Design. Cohort study.Setting. A healthcare database containing the electronic GP medical records of over 1.5 million patients throughout the Netherlands.Patients. A total of 16 626 adult patients with MSK complaints prescribed an NSAID.Main outcome measures. The patients’ medical records were manually assessed for the duration of NSAID use for a maximum of two months, and consultations for complaints predefined as potential ADRs were identified. Subsequently, the likelihood of an association with the NSAID use was assessed and these potential ADRs were categorized as likely, possible, or unlikely ADRs.Results. In total, 961 patients (6%) consulted their GP with 1227 non-serious potential ADRs. In 174 patients (1%) at least one of these was categorized as a likely ADR, and in a further 408 patients (2.5%) at least one was categorized as a possible ADR. Dyspepsia was the most frequent likely ADR, followed by diarrhoea and dyspnoea (respectively 34%, 8%, and 8% of all likely ADRs).Conclusion. Of the patients with MSK complaints prescribed an NSAID, almost one in 30 patients re-consulted their GP with a complaint likely or possibly associated with the use of this drug. The burden of such consultations for non-serious ADRs should be taken into account by GPs when deciding whether treatment with an NSAID is appropriate. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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