Evaluation of multiple comparison correction procedures in drug assessment studies using LORETA maps.
The identification of the brain regions involved in the neuropharmacological action is a potential procedure for drug development. These regions are commonly determined by the voxels showing significant statistical differences after comparing placebo-induced effects with drug-elicited effects. LORET...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 53; no. 10; pp. 1011 - 1024 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110401385&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110401385 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Oct2015 vid: 53 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 110401385 110401385 NLM26040586 110401385 10.1007/s11517-015-1315-6 NLM26040586 110401385 ppf: 1011 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Evaluation of multiple comparison correction procedures in drug assessment studies using LORETA maps. aug: au: Alonso, Joan Romero, Sergio Mañanas, Miguel Rojas, Mónica Riba, Jordi Barbanoj, Manel Alonso, Joan Francesc Mañanas, Miguel Ángel Rojas, Mónica Barbanoj, Manel José affil: Department of Automatic Control, Biomedical Engineering Research Center, Universitat Politècnica de Catalunya. BarcelonaTech (UPC), Barcelona, Spain sug: subj: Central Nervous System Agents Pharmacodynamics Electroencephalography Methods Brain Mapping Methods Brain Drug Effects Male Cluster Analysis Alprazolam Pharmacodynamics Brain Physiology Young Adult Algorithms Adult Human Adult: 19-44 years Male ab: The identification of the brain regions involved in the neuropharmacological action is a potential procedure for drug development. These regions are commonly determined by the voxels showing significant statistical differences after comparing placebo-induced effects with drug-elicited effects. LORETA is an electroencephalography (EEG) source imaging technique frequently used to identify brain structures affected by the drug. The aim of the present study was to evaluate different methods for the correction of multiple comparisons in the LORETA maps. These methods which have been commonly used in neuroimaging and also simulated studies have been applied on a real case of pharmaco-EEG study where the effects of increasing benzodiazepine doses on the central nervous system measured by LORETA were investigated. Data consisted of EEG recordings obtained from nine volunteers who received single oral doses of alprazolam 0.25, 0.5, and 1 mg, and placebo in a randomized crossover double-blind design. The identification of active regions was highly dependent on the selected multiple test correction procedure. The combined criteria approach known as cluster mass was useful to reveal that increasing drug doses led to higher intensity and spread of the pharmacologically induced changes in intracerebral current density. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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