The effect of sleep deprivation on pain perception in healthy subjects: a meta-analysis.

Background: There is strong evidence indicating an interaction between sleep and pain. However, the size of this effect, as well as the clinical relevance, is unclear. Therefore, this meta-analysis was conducted to quantify the effect of sleep deprivation on pain perception.Methods: A systematic lit...

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Publicado en:Sleep Medicine Vol. 16; no. 11; pp. 1313 - 1321
Autores principales: Schrimpf, Marlene, Liegl, Gregor, Boeckle, Markus, Leitner, Anton, Geisler, Peter, Pieh, Christoph
Formato: meta analysis research Journal Article
Publicado: Elsevier B.V. Nov2015
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2015
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      pub: Elsevier B.V.
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        10.1016/j.sleep.2015.07.022
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        110432943
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        atl: The effect of sleep deprivation on pain perception in healthy subjects: a meta-analysis.
      aug:
        au:
          Schrimpf, Marlene
          Liegl, Gregor
          Boeckle, Markus
          Leitner, Anton
          Geisler, Peter
          Pieh, Christoph
        affil: Department of Psychotherapy and Biopsychosocial Health, Danube-University Krems, Dr. Karl Dorrek Straße 30, A-3500 Krems, Austria
      sug:
        subj:
          Research Subjects Psychosocial Factors
          Sleep Deprivation Psychosocial Factors
          Pain Physiology
          Human
          Pain Measurement
          Meta Analysis
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
      ab: Background: There is strong evidence indicating an interaction between sleep and pain. However, the size of this effect, as well as the clinical relevance, is unclear. Therefore, this meta-analysis was conducted to quantify the effect of sleep deprivation on pain perception.Methods: A systematic literature search was conducted using the electronic databases PubMed, Cochrane, Psyndex, Psycinfo, and Scopus. By conducting a random-effect model, the pooled standardized mean differences (SMDs) of sleep deprivation on pain perception was calculated. Studies that investigated any kind of sleep deprivation in conjunction with a pain measurement were included. In cases of several pain measurements within a study, the average effect size of all measures was calculated.Results: Five eligible studies (N = 190) for the between-group analysis and ten studies (N = 266) for the within-group analysis were identified. Sleep deprivation showed a medium effect in the between-group analysis (SMD = 0.62; CI95: 0.12, 1.12; z = 2.43; p = 0.015) and a large effect in the within-group analysis (SMD = 1.49; CI95: 0.82, 2.17; z = 4.35; p <0.0001). The test for heterogeneity was not significant in the between-group analysis (Q = 5.29; df = 4; p = 0.2584), but it was significant in the within-group analysis (Q = 53.49; df = 9; p <0.0001).Conclusion: This meta-analysis confirms a medium effect (SMD = 0.62) of sleep deprivation on pain perception. As this meta-analysis is based on experimental studies in healthy subjects, the clinical relevance should be clarified.
      pubtype: Academic Journal
      doctype:
        meta analysis
        research
        Journal Article
      ougenre: Article
    language: English
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