Outcome of second- and third-line Helicobacter pylori eradication therapies based on antimicrobial susceptibility testing.
Objectives: The objective of this study was to assess the outcome of antimicrobial susceptibility-guided therapies in Helicobacter pylori-infected individuals who had undergone unsuccessful prior eradication treatments.Methods: From October 2004 to December 2013, 481 H. pylori-positive patients with...
| Publicado en: | Journal of Antimicrobial Chemotherapy (JAC) Vol. 70; no. 11; pp. 3141 - 3146 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110493303&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110493303 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03057453 N5O jtl: Journal of Antimicrobial Chemotherapy (JAC) issn: 03057453 maglogo: N pubinfo: dt: Nov2015 vid: 70 iid: 11 pid: 622 pub: Oxford University Press / USA artinfo: ui: 110493303 110493303 NLM26245638 110493303 10.1093/jac/dkv223 NLM26245638 110493303 ppf: 3141 ppct: 5 formats: tig: atl: Outcome of second- and third-line Helicobacter pylori eradication therapies based on antimicrobial susceptibility testing. aug: au: Draeger, Sarah Wüppenhorst, Nicole Kist, Manfred Glocker, Erik-Oliver affil: National Reference Centre for Helicobacter pylori, Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany sug: subj: Antibiotics Therapeutic Use Salvage Therapy Methods Helicobacter Pylori Helicobacter Infections Drug Therapy Female Biopsy Breath Tests Helicobacter Infections Microbiology Retrospective Design Feces Microbiology Urea Analysis Antigens, Bacterial Analysis Treatment Outcomes Histocytochemistry Gastric Mucosa Pathology Male Enzyme-Linked Immunosorbent Assay Microbial Culture and Sensitivity Tests Drug Therapy, Combination Methods Human Female Male ab: Objectives: The objective of this study was to assess the outcome of antimicrobial susceptibility-guided therapies in Helicobacter pylori-infected individuals who had undergone unsuccessful prior eradication treatments.Methods: From October 2004 to December 2013, 481 H. pylori-positive patients with prior unsuccessful eradication treatments were administered susceptibility-guided salvage eradication treatments. Six months on, treatment outcome was assessed by urea breath test, stool antigen ELISA, Helicobacter urease test or microbiology and/or histopathology.Results: Resistance to metronidazole and clarithromycin was high in patients with prior unsuccessful eradication treatments and was dependent on the number of treatment failures. Susceptibility-guided salvage eradication treatments achieved eradication rates of nearly 70% in these patients. No particular regimen was significantly better than another.Conclusions: Antimicrobial susceptibility testing prevents prescription of inefficient antimicrobials and enables individualized and promising salvage treatments in patients with prior unsuccessful eradication treatments. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|