Ambulatory Blood Pressures in Hypertensive Patients Treated With One Antihypertensive Agent: Differences Among Drug Classes and Among Drugs Belonging to the Same Class.

The authors investigated the differences in office and ambulatory blood pressure (BP) among major antihypertensive drug classes and among frequently used drugs in each class in 22,617 patients treated with monotherapy from the Spanish ABPM Registry. Using thiazides as the reference group, patients t...

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Publicado en:Journal of Clinical Hypertension Vol. 17; no. 11; pp. 857 - 866
Autores principales: Sierra, Alejandro, Gorostidi, Manuel, Banegas, José R., Segura, Julián, Vinyoles, Ernest, Cruz, Juan J., Ruilope, Luis M., de la Sierra, Alejandro, Banegas, José R, de la Cruz, Juan J
Formato: research Journal Article
Publicado: Wiley-Blackwell Nov2015
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2015
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1111/jch.12623
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        atl: Ambulatory Blood Pressures in Hypertensive Patients Treated With One Antihypertensive Agent: Differences Among Drug Classes and Among Drugs Belonging to the Same Class.
      aug:
        au:
          Sierra, Alejandro
          Gorostidi, Manuel
          Banegas, José R.
          Segura, Julián
          Vinyoles, Ernest
          Cruz, Juan J.
          Ruilope, Luis M.
          de la Sierra, Alejandro
          Banegas, José R
          Segura, Julián
          de la Cruz, Juan J
        affil: Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Barcelona Spain
      sug:
        subj:
          Hypertension Drug Therapy
          Antihypertensive Agents Therapeutic Use
          Angiotensin II Type I Receptor Blockers Therapeutic Use
          Angiotensin-Converting Enzyme Inhibitors Therapeutic Use
          Middle Age
          Adrenergic beta-Antagonists Therapeutic Use
          Male
          Female
          Blood Pressure Drug Effects
          Calcium Channel Blockers Therapeutic Use
          Antihypertensive Agents Pharmacodynamics
          Blood Pressure Monitoring, Ambulatory Methods
          Antihypertensive Agents Classification
          Hypertension Physiopathology
          Middle Aged: 45-64 years
          Male
          Female
      ab: The authors investigated the differences in office and ambulatory blood pressure (BP) among major antihypertensive drug classes and among frequently used drugs in each class in 22,617 patients treated with monotherapy from the Spanish ABPM Registry. Using thiazides as the reference group, patients treated with calcium channel blockers have significantly (P<.01) elevated ambulatory BP and less ambulatory control after adjusting for confounders. Inside each class, no significant differences were observed among thiazides or angiotensin receptor blockers. Atenolol and bisoprolol among β-blockers, amlodipine among calcium channel blockers, and lisinopril and enalapril among angiotensin-converting enzyme inhibitors exhibited lower ambulatory BP and better control than other agents. Differences exist among antihypertensive drug classes and among different compounds in each class with respect to ambulatory BP control. This can help physicians choose among drug classes and among compounds in each class if BP reduction is the main objective of treatment.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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