Iron deposition influences the measurement of water diffusion tensor in the human brain: a combined analysis of diffusion and iron-induced phase changes.
Introduction: This study aims to evaluate the impact of iron deposition during aging on the measurement of water diffusion in the brain. Methods: Diffusion tensor images (DTI) and phase images collected from a group of healthy adults from 23 to 72 years old were retrospectively analyzed. The axial d...
| Publicado en: | Neuroradiology Vol. 57; no. 11; pp. 1169 - 1179 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110606524&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110606524 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2015 vid: 57 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 110606524 110606524 110606524 10.1007/s00234-015-1579-4 NLM26307228 110606524 ppf: 1169 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Iron deposition influences the measurement of water diffusion tensor in the human brain: a combined analysis of diffusion and iron-induced phase changes. aug: au: Xu, Xiaojun Wang, Qidong Zhong, Jianhui Zhang, Minming affil: Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road Hangzhou China 310009 sug: subj: Brain Analysis Gray Matter Statistical Significance Diffusion Water Aged Aged: 65+ years ab: Introduction: This study aims to evaluate the impact of iron deposition during aging on the measurement of water diffusion in the brain. Methods: Diffusion tensor images (DTI) and phase images collected from a group of healthy adults from 23 to 72 years old were retrospectively analyzed. The axial diffusivity, radial diffusivity, mean diffusivity (MD), and fractional anisotropy (FA) in the frontal white matter and deep gray matter nuclei were calculated. The phase changes in these regions were used to estimate local iron concentration. Pearson correlation analysis was used to evaluate the age dependence of DTI metrics and iron concentration. Multiple linear regression models were then built to examine the independent effect of age and iron deposition on DTI metrics. Results: Age-related iron deposition occurred in the putamen ( r = 0.680, P < 0.001) and frontal white matter ( r = 0.333, P = 0.007). In the putamen, FA increased with elevated iron concentration ( P = 0.042) excluding the effect of age, and MD decreased with iron deposition with marginal statistical significance ( P = 0.067). In the frontal white matter, increase in iron level was also associated with a decrease in MD and an increase in FA. Moreover, radial diffusivity was more reduced than axial diffusivity as local iron concentration increased. Conclusion: Iron deposition in the brain during aging decreases water diffusion and increases the degree of anisotropy. Caution is needed when using DTI metrics for diagnosis of various neurological diseases involving abnormal iron deposition. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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