Paradoxical perfusion metrics of high-grade gliomas with an oligodendroglioma component: quantitative analysis of dynamic susceptibility contrast perfusion MR imaging.
Introduction: The aim of this study is to investigate perfusion characteristics of glioblastoma with an oligodendroglioma component (GBMO) compared with conventional glioblastoma (GBM) using dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) imaging and microvessel density (MVD)...
| Publicado en: | Neuroradiology Vol. 57; no. 11; pp. 1111 - 1121 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110606530&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110606530 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2015 vid: 57 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 110606530 110606530 110606530 10.1007/s00234-015-1569-6 NLM26232204 110606530 ppf: 1111 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Paradoxical perfusion metrics of high-grade gliomas with an oligodendroglioma component: quantitative analysis of dynamic susceptibility contrast perfusion MR imaging. aug: au: Sunwoo, Leonard Choi, Seung Yoo, Roh-Eul Kang, Koung Yun, Tae Kim, Tae Lee, Se-Hoon Park, Chul-Kee Kim, Ji-hoon Park, Sun-Won Sohn, Chul-Ho Won, Jae-Kyung Park, Sung-Hye Kim, Il affil: Department of Internal Medicine, Seoul National University Hospital, Seoul Korea sug: subj: Cerebral Blood Volume Institutional Review Neoplasm Grading Perfusion Imaging Magnetic Resonance Spectroscopy ab: Introduction: The aim of this study is to investigate perfusion characteristics of glioblastoma with an oligodendroglioma component (GBMO) compared with conventional glioblastoma (GBM) using dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) imaging and microvessel density (MVD). Methods: The study was approved by the institutional review board. Newly diagnosed high-grade glioma patients were enrolled ( n = 72; 20 GBMs, 14 GBMOs, 19 anaplastic astrocytomas (AAs), 13 anaplastic oligodendrogliomas (AOs), and six anaplastic oligoastrocytomas (AOAs)). All participants underwent preoperative MR imaging including DSC perfusion MR imaging. Normalized cerebral blood volume (nCBV) values were analyzed using a histogram approach. Histogram parameters were subsequently compared across each tumor subtype and grade. MVD was quantified by immunohistochemistry staining and correlated with perfusion parameters. Progression-free survival (PFS) was assessed according to the tumor subtype. Results: GBMO displayed significantly reduced nCBV values compared with GBM, whereas grade III tumors with oligodendroglial components (AO and AOA) exhibited significantly increased nCBV values compared with AA ( p < 0.001). MVD analyses revealed the same pattern as nCBV results. In addition, a positive correlation between MVD and nCBV values was noted ( r = 0.633, p < 0.001). Patients with oligodendroglial tumors exhibited significantly increased PFS compared with patients with pure astrocytomas in each grade. Conclusion: In contrast to grade III tumors, the presence of oligodendroglial components in grade IV tumors resulted in paradoxically reduced perfusion metrics and MVD. In addition, patients with GBMO exhibited a better clinical outcome compared with patients with GBM. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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