Frequency of γδ T Cells and Invariant Natural Killer T Cells in Helicobacter Pylori-infected Patients with Peptic Ulcer and Gastric Cancer.
To clarify the effect of γδ T cells and invariant Natural Killer T (iNKT) cells in pathophysiology of dyspeptic disorders, number of these two cells in patients with non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), and gastric cancer (GC) were compared.Patients with dyspepsia were divided into...
| Publicado en: | Iranian Journal of Allergy, Asthma & Immunology Vol. 14; no. 5; pp. 493 - 502 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Tehran University of Medical Sciences
Oct2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110614383&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110614383 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17351502 87XG jtl: Iranian Journal of Allergy, Asthma & Immunology issn: 17351502 maglogo: N pubinfo: dt: Oct2015 vid: 14 iid: 5 pid: 21783 pub: Tehran University of Medical Sciences artinfo: ui: 110614383 110614383 NLM26742438 110614383 NLM26742438 110614383 ppf: 493 ppct: 9 formats: tig: atl: Frequency of γδ T Cells and Invariant Natural Killer T Cells in Helicobacter Pylori-infected Patients with Peptic Ulcer and Gastric Cancer. aug: au: Shadman, Mojtaba Rajabian, Zeinab Ajami, Abolghasem Hussein-Nattaj, Hadi Rafiei, Alireza Hosseini, Vahid Taghvaei, Tarang Abbasi, Ali Tehrani, Mohsen affil: Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran sug: subj: Peptic Ulcer Immunology Adenocarcinoma Immunology T Lymphocytes Immunology Receptors, Cell Surface Metabolism Dyspepsia Immunology Helicobacter Infections Immunology Stomach Neoplasms Immunology Stomach Neoplasms Pathology T Lymphocytes Receptors, Cell Surface Immunology Helicobacter Pylori Dyspepsia Pathology Stomach Neoplasms Metabolism Endoscopy, Digestive System Adult Immunohistochemistry Middle Age Dyspepsia Metabolism Female Male Stomach Immunology Flow Cytometry Helicobacter Infections Metabolism Helicobacter Infections Pathology Peptic Ulcer Pathology Peptic Ulcer Metabolism Aged Adenocarcinoma Pathology Biopsy Adenocarcinoma Metabolism Stomach Metabolism Stomach Pathology Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: To clarify the effect of γδ T cells and invariant Natural Killer T (iNKT) cells in pathophysiology of dyspeptic disorders, number of these two cells in patients with non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), and gastric cancer (GC) were compared.Patients with dyspepsia were divided into three groups of NUD, PUD, and GC according to their endoscopic and histopathological examinations. Helicobacter pylori infection was diagnosed by rapid urease test and histopathology. The number of peripheral blood CD3+TCRγδ(+) T cells and CD3+Va24Ja18+ iNKT cells were determined by flow cytometry. Immunohistochemistry (IHC) was also used for identifying the TCRγδ+ cells.Forty two patients with NUD (31.6%), 44 with PUD (33.1%), and 47 with GC (35.3%) were included in the study. The frequency of CD3+TCRγδ(+) T cells in peripheral blood of patients with GC (2.71±0.25) was significantly lower than that in NUD (3.97±0.32, p<0.05) and PUD groups (3.87±0.32, p<0.05). However, there was no significant difference in CD3+TCRγδ(+) T cell percentage between the NUD and PUD groups. The frequency of TCRγδ(+) lymphocytes was significantly lower in tissue samples from patients with GC (4.81±0.53) than in NUD (11.09±1.09, p<0.0001) and PUD groups (11.11±1.01, p<0.0001). Also, we could not find any significant difference in the percentage of mucosal TCRγδ+ cells between the NUD and PUD groups. The results showed no significant difference in iNKT cells percentage among the three groups of patients.The results suggest that decreasing number of γδ T cells may be related to development and progression of gastric cancer. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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