Serological comparison of serum pepsinogen and anti-parietal cell antibody levels between Japanese and German patients.
Background: Atrophic gastritis is more common in Japan than in Germany. The expression of anti-parietal cell antibody has been implicated in the genesis of atrophic gastritis associated with Helicobacter pylori infection.Objective: We investigated the difference in serum levels of pepsinogens and in...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 14; no. 2; pp. 123 - 128 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Feb2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110639790&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110639790 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Feb2002 vid: 14 iid: 2 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110639790 110639790 NLM11981335 110639790 10.1097/00042737-200202000-00005 NLM11981335 110639790 ppf: 123 ppct: 5 formats: tig: atl: Serological comparison of serum pepsinogen and anti-parietal cell antibody levels between Japanese and German patients. aug: au: Ito, Masanori Haruma, Ken Kaya, Shunji Kamada, Tomoari Kim, Sunjin Sasaki, Atsunori Sumii, Masaharu Tanaka, Shinji Yoshihara, Masaharu Wagner, Siegfried Chayama, Kazuaki affil: First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan; bHealth Service Centre, Hiroshima University, Hiroshima, Japan; cDivision of Gastroenterology II, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan; dBiological Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan; and eDepartment of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany sug: subj: Gastritis, Atrophic Immunology Antibodies Analysis Enzymes Blood Gastric Mucosa Immunology Adolescence Male Immunohistochemistry Disease Progression Middle Age Aged, 80 and Over Adult Japan Female Helicobacter Pylori Epidemiological Research Enzyme-Linked Immunosorbent Assay Germany Aged Radioimmunoassay Human Child Helicobacter Infections Immunology Gastritis, Atrophic Epidemiology Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adolescent: 13-18 years Middle Aged: 45-64 years Aged, 80 & over Adult: 19-44 years Aged: 65+ years Child: 6-12 years Male Female ab: Background: Atrophic gastritis is more common in Japan than in Germany. The expression of anti-parietal cell antibody has been implicated in the genesis of atrophic gastritis associated with Helicobacter pylori infection.Objective: We investigated the difference in serum levels of pepsinogens and in anti-parietal cell antibody expression between Japanese and German patients.Methods: We recruited 102 Japanese and 46 German patients with dyspepsia. Endoscopic examination detected no localized lesions in the upper gastrointestinal tract of any patients. Anti-parietal cell antibody was investigated by enzyme-linked immunosorbent assay with the purified porcine H+,K+-ATPase fraction and immunohistochemistry. H. pylori infection was diagnosed by the presence of anti-H. pylori antibody, by using the urease test and by histological examination. Serum levels of pepsinogen I and II and of gastrin were measured by a modified radioimmunoassay.Results: Seventy-one Japanese (70%) and 17 Germans (37%) were positive for H. pylori. Serum levels of anti-parietal cell antibody were not significantly different between Japanese and Germans in both H. pylori negative and positive groups. The serum pepsinogen I/II ratio and gastrin levels were altered by H. pylori infection in both populations. Moreover, anti-parietal cell antibody levels were higher in H. pylori-positive patients with low pepsinogen levels than in those with high pepsinogen levels in both populations.Conclusions: The levels of anti-parietal cell antibody do not differ statistically between Japanese and Germans. Anti-parietal cell antibody might play a role in the progression of atrophic gastritis in both Japanese and German patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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