Overlapping syndrome of autoimmune hepatitis and primary sclerosing cholangitis associated with pyoderma gangrenosum and ulcerative colitis.
We describe the case of a 18-year-old male patient who first presented with decompensated cirrhosis, fever and generalized lymphadenopathy. He had abnormal results for liver biochemical tests, with a hepatitic-like picture and high titre of antinuclear antibodies. According to the scoring system pro...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 11; no. 12; pp. 1421 - 1425 |
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| Autores principales: | , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Dec1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110639817&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110639817 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Dec1999 vid: 11 iid: 12 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110639817 110639817 NLM10654805 110639817 10.1097/00042737-199912000-00014 NLM10654805 110639817 ppf: 1421 ppct: 4 formats: tig: atl: Overlapping syndrome of autoimmune hepatitis and primary sclerosing cholangitis associated with pyoderma gangrenosum and ulcerative colitis. aug: au: Koskinas, John Rapts, Irene Manika, Zisoula Hadziyannis, Stephanos Koskinas, J Raptis, I Manika, Z Hadziyannis, S affil: Academic Department of Medicine, Hippokration General Hospital, Athens, Greece sug: subj: Cholangitis, Sclerosing Complications Hepatitis, Autoimmune Complications Hepatitis, Autoimmune Therapy Liver Transplantation Pyoderma Gangrenosum Complications Colitis, Ulcerative Complications Male Pyoderma Gangrenosum Drug Therapy Cyclosporine Therapeutic Use Immunosuppressive Agents Therapeutic Use Adolescence Cholangitis, Sclerosing Drug Therapy Adolescent: 13-18 years Male ab: We describe the case of a 18-year-old male patient who first presented with decompensated cirrhosis, fever and generalized lymphadenopathy. He had abnormal results for liver biochemical tests, with a hepatitic-like picture and high titre of antinuclear antibodies. According to the scoring system proposed by the International Autoimmune Hepatitis Group he had 'definite' autoimmune hepatitis and responded well to immunosuppressive treatment. One year later he developed pyoderma gangrenosum which was successfully treated with cyclosporine. Two years later he experienced bloody diarrhoea as a first presentation of ulcerative colitis. At that time both the cholestatic biochemical picture and the cholangiographic appearances of the biliary tree were consistent with primary sclerosing cholangitis. Despite the addition of azathioprine and ursodeoxycholic acid to his treatment regime he developed recurrent episodes of cholangitis and intractable pruritus for which he underwent successful liver transplantation. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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