A comparison of two rapid whole-blood tests and laboratory serology, in the diagnosis of Helicobacter pylori infection.
Objective: To compare two rapid whole-blood serology tests for Helicobacter pylori and a laboratory serology assay against a gold standard.Design: Prospective comparison of tests in 81 patients.Setting: A hospital rapid access endoscopy clinic.Participants: Dyspeptic patients requiring assessment of...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 11; no. 8; pp. 863 - 866 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Aug1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110640224&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110640224 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Aug1999 vid: 11 iid: 8 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110640224 110640224 NLM10514118 110640224 10.1097/00042737-199908000-00009 NLM10514118 110640224 ppf: 863 ppct: 3 formats: tig: atl: A comparison of two rapid whole-blood tests and laboratory serology, in the diagnosis of Helicobacter pylori infection. aug: au: Hawthorne, A. Barney Morgan, Shirley Westmoreland, Diana Stenson, Rachel Thomas, Gareth A. O. Newcombe, Robert G. Hawthorne, A B Morgan, S Westmoreland, D Stenson, R Thomas, G A Newcombe, R G affil: Departments of aMedicine, and bMedical Microbiology and Public Health, University Hospital of Wales, Heath Park, Cardiff; and cMedical Computing and Statistics, University of Wales College of Medicine, Cardiff CF4 4XW, UK sug: subj: Helicobacter Infections Blood Helicobacter Infections Diagnosis Helicobacter Pylori Serologic Tests Methods Isotopes Urea Metabolism Helicobacter Pylori Metabolism Prospective Studies Middle Age Reagent Kits, Diagnostic Adult Human Predictive Value of Tests Aged Evaluation Research Gastric Mucosa Microbiology Adolescence Aged, 80 and Over Sensitivity and Specificity Breath Tests Validation Studies Comparative Studies Multicenter Studies Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Adolescent: 13-18 years Aged, 80 & over ab: Objective: To compare two rapid whole-blood serology tests for Helicobacter pylori and a laboratory serology assay against a gold standard.Design: Prospective comparison of tests in 81 patients.Setting: A hospital rapid access endoscopy clinic.Participants: Dyspeptic patients requiring assessment of H. pylori status.Interventions: Measurement of H. pylori antibody status by Quickvue One-step, Helisal, and Premier H. pylori test; 13C urea breath test for H. pylori, and gastric biopsies for histology, culture and rapid urease test.Main Outcome Measure: Sensitivity and specificity of Quickvue One-step, Helisal and Premier tests, compared to a gold standard based on 13C urea breath test, biopsy culture, histology and urease test.Results: The Quickvue assay has significantly greater sensitivity (81%) than Helisal (67%), but without appreciable loss of specificity (86% and 93%, respectively). The Premier laboratory assay is significantly more sensitive than both of the rapid blood tests (96%), with comparable specificity to the Quickvue assay.Conclusion: The rapid serology tests used in this study are quick and convenient to use, but do not approach the sensitivity of a laboratory assay in detecting H. pylori status in this group of dyspeptic patients attending an endoscopy clinic. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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