Multiple myeloma involving the stomach with vitamin B12 deficiency.
Involvement of the gastrointestinal tract by plasmocytoma is rare. In a 78-year-old man with IgA lambda multiple myeloma stage IIIB, the evaluation of a megaloblastic anaemia revealed a subnormal vitamin B12 level. Urinary excretion of isotope-labelled vitamin B12 was reduced. Tests for gastric pari...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 11; no. 2; pp. 205 - 208 |
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| Autores principales: | , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Feb1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110640388&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110640388 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Feb1999 vid: 11 iid: 2 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110640388 110640388 NLM10102234 110640388 10.1097/00042737-199902000-00024 NLM10102234 110640388 ppf: 205 ppct: 3 formats: tig: atl: Multiple myeloma involving the stomach with vitamin B12 deficiency. aug: au: Doberauer, Claus Sanner, Bernd Henning, Bernhard Doberauer, C Sanner, B Henning, B affil: Department I of Internal Medicine, Ruhr-University Bochum, Marienhospital Heme, Germany sug: subj: Stomach Neoplasms Complications Multiple Myeloma Complications Avitaminosis Etiology Helicobacter Infections Complications Anemia, Macrocytic Etiology Helicobacter Pylori Classification Immunoglobulins Analysis Multiple Myeloma Immunology B Lymphocytes Pathology Stomach Neoplasms Immunology Multiple Myeloma Pathology Neoplasm Staging Aged Gastric Mucosa Pathology Stomach Neoplasms Pathology Male Scales Aged: 65+ years Male ab: Involvement of the gastrointestinal tract by plasmocytoma is rare. In a 78-year-old man with IgA lambda multiple myeloma stage IIIB, the evaluation of a megaloblastic anaemia revealed a subnormal vitamin B12 level. Urinary excretion of isotope-labelled vitamin B12 was reduced. Tests for gastric parietal cell and intrinsic factor antibodies were negative. There were no clinical signs of an insufficient absorption in the ileum. Biopsy specimens of the stomach showed a dense, diffuse infiltrate of malignant plasma cells in the lamina propria of fundus and corpus. A urease test for Helicobacter pylori was positive. There was a minor haematological improvement when vitamin B12 was given parenterally. Several combinations of cytostatic drugs had no effect on the manifestations of the multiple myeloma. In our patient the vitamin B12 deficiency may be related to a displacement or destruction of parietal cells by malignant plasma cells. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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