Which Helicobacter pylori-positive dyspeptics are likely to respond symptomatically to empirical H. pylori eradication?
Objective: To identify which Helicobacter pylori-positive dyspeptic patients have an increased likelihood of having peptic ulcer and may thus be more likely to benefit from empirical H. pylori eradication therapy.Methods: 622 out of 740 consecutive dyspeptic subjects (median age 45 years, range 14-9...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 10; no. 3; pp. 265 - 269 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Mar1998
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110640851&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110640851 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Mar1998 vid: 10 iid: 3 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110640851 110640851 NLM9585033 110640851 10.1097/00042737-199803000-00014 NLM9585033 110640851 ppf: 265 ppct: 4 formats: tig: atl: Which Helicobacter pylori-positive dyspeptics are likely to respond symptomatically to empirical H. pylori eradication? aug: au: Asante, Maxwell A. Mendall, Michael A. Northfield, Timothy C. Asante, M A Mendall, M A Northfield, T C affil: Department of Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, London, UK sug: subj: Dyspepsia Drug Therapy Helicobacter Pylori Peptic Ulcer Epidemiology Helicobacter Infections Drug Therapy Predictive Value of Tests Male Human Aged, 80 and Over Middle Age Smoking Adolescence Aged Risk Factors Dyspepsia Microbiology Sensitivity and Specificity Female Adult Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged, 80 & over Middle Aged: 45-64 years Adolescent: 13-18 years Aged: 65+ years Adult: 19-44 years Male Female ab: Objective: To identify which Helicobacter pylori-positive dyspeptic patients have an increased likelihood of having peptic ulcer and may thus be more likely to benefit from empirical H. pylori eradication therapy.Methods: 622 out of 740 consecutive dyspeptic subjects (median age 45 years, range 14-91, 51% male) attending for rapid access endoscopy were eligible for the study. Demographic data and endoscopic findings were recorded. H. pylori status was determined by urease and histology.Results: In all age groups, peptic ulcers were commoner in males than females [44% (85/195) vs 23% (32/139), P < 0.001] and in smokers than non-smokers [47% (46/97) vs 32% (50/159), P < 0.05]. Males, heavy smokers and those with a family history of peptic ulcer had increased adjusted odds of having a peptic ulcer (2.59, 1.96 and 1.90, respectively). Corresponding odds ratios for those aged under 45 were 2.59, 0.94 and 2.52. In H. pylori-positive dyspepsia, being a male who either smoked heavily or had a family history of peptic ulcer gave a sensitivity and positive predictive value for peptic ulcer of 86 and 45% for all age groups and 85 and 49% for those aged under 45.Conclusion: Male H. pylori dyspeptics who smoke >10 cigarettes per day and/or have a family history of peptic ulcer are likely to have peptic ulcer and are thus likely to benefit from empirical eradication therapy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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