Antral and fundic D-cell numbers in Helicobacter pylori infection.
Objectives: Helicobacter pylori infection is associated with an exaggeration of gastrin release following meals or bombesin stimulation attributed to a defect of somatostatin secretion of antral D-cells. Nevertheless, these modifications of gastric physiology do not explain the increase of gastric a...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 9; no. 4; pp. 361 - 366 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Apr1997
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110641055&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110641055 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Apr1997 vid: 9 iid: 4 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110641055 110641055 NLM9160198 110641055 10.1097/00042737-199704000-00008 NLM9160198 110641055 ppf: 361 ppct: 5 formats: tig: atl: Antral and fundic D-cell numbers in Helicobacter pylori infection. aug: au: Chamouard, Patrick Walter, Paul Wittersheim, Christian Demuynck, Phillippe Meunier, Olivier Baumann, René Chamouard, P Walter, P Wittersheim, C Demuynck, P Meunier, O Baumann, R affil: From the 1Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, CHRU Hautepierre, Strasbourg, 2Institut de Pathologie Faculté de Médecine, Strasbourg and 3Laboratoire de Bactériologie Faculté de Médecine, Strasbourg, France. sug: subj: Helicobacter Infections Pathology Pyloric Antrum Pathology Gastric Fundus Pathology Human Male Helicobacter Infections Metabolism Prospective Studies Duodenal Ulcer Pathology Gastric Mucosa Microbiology Helicobacter Pylori Helicobacter Infections Microbiology Biopsy Pyloric Antrum Metabolism Cell Count Duodenal Ulcer Metabolism Female Gastric Mucosa Metabolism Adult Somatostatin Metabolism Gastric Fundus Metabolism Immunohistochemistry Gastric Mucosa Pathology Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Male Female ab: Objectives: Helicobacter pylori infection is associated with an exaggeration of gastrin release following meals or bombesin stimulation attributed to a defect of somatostatin secretion of antral D-cells. Nevertheless, these modifications of gastric physiology do not explain the increase of gastric acid secretion which is only observed in duodenal ulcer patients. The inhibitory effect of somatostatin secretion of fundic D-cells on parietal cells is well known. The aim of our prospective study was to compare the number of fundic D-cells and likewise the number of antral G-cells and D-cells between patients with duodenal ulcer and healthy subjects with and without H. pylori infection.Methods: The numbers of D-cells and G-cells were compared between 19 infected patients with duodenal ulcer and 20 healthy subjects, 10 with and 10 without H. pylori infection. Fundic mucosal biopsy specimens were examined using immunohistochemical techniques specific for the presence of somatostatin, antral mucosal biopsy specimens for the presence of gastrin and somatostatin.Results: The number of G-cells was significantly lower (P = 0.0012) in duodenal ulcer patients by comparison with infected subjects and controls. The number of antral D-cells was significantly less (P < 0.0001) in duodenal ulcer patients (mean of 10 random fields = 0.45 +/- 0.04) than in either asymptomatic infected patients (0.65 +/- 0.07) or uninfected controls (0.88 +/- 0.10). The number of fundic D-cells was significantly lower (P < 0.0001) in duodenal ulcer patients (mean = 0.20 +/- 0.03) than in either asymptomatic infected subjects (0.29 +/- 0.05) or controls (0.73 +/- 0.09); here the difference between the two groups of infected subjects was not significant. Multivariate analysis showed that the presence of H. pylori infection of the fundic mucosa did not influence the number of fundic D-cells.Conclusion: Changes in the number of fundic and antral D-cells induced by H. pylori infection did not explain abnormalities of gastric acid secretion usually observed in duodenal ulcer patients; it is suggested that pre-existing abnormalities in the regulation of parietal cell or increase of parietal cell mass are involved. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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