Pancreatic neuroendocrine tumors: correlation between histogram analysis of apparent diffusion coefficient maps and tumor grade.
Purpose: To explore the role of histogram analysis of apparent diffusion coefficient (ADC) MRI maps based on entire tumor volume data in determining pancreatic neuroendocrine tumor (PNT) grade.Methods and Materials: Retrospective evaluation of 22 patients with PNTs included low-grade (G1; n = 15), i...
| Published in: | Abdominal Imaging Vol. 40; no. 8; pp. 3122 - 3129 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Oct2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110653811&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110653811 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09428925 O52 jtl: Abdominal Imaging issn: 09428925 maglogo: N pubinfo: dt: Oct2015 vid: 40 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 110653811 110653811 NLM26280127 10.1007/s00261-015-0524-7 NLM26280127 110653811 ppf: 3122 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Pancreatic neuroendocrine tumors: correlation between histogram analysis of apparent diffusion coefficient maps and tumor grade. aug: au: Pereira, Jose Rosado, Elsa Bali, Maria Metens, Thierry Chao, Shih-Li Pereira, Jose Antonio Sousa affil: Department of Radiology, Centro Hospitalar de Lisboa Central, Lisbon Portugal sug: subj: Pancreatic Neoplasms Pathology Neuroendocrine Tumors Pathology Magnetic Resonance Imaging Reproducibility of Results Image Interpretation, Computer Assisted Neoplasm Grading Pancreas Pathology Middle Age Adult Aged Male Sensitivity and Specificity Female Retrospective Design Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Purpose: To explore the role of histogram analysis of apparent diffusion coefficient (ADC) MRI maps based on entire tumor volume data in determining pancreatic neuroendocrine tumor (PNT) grade.Methods and Materials: Retrospective evaluation of 22 patients with PNTs included low-grade (G1; n = 15), intermediate-grade (G2; n = 4), and high-grade (G3; n = 3) tumors. Regions of interest containing the lesion were drawn on every section of the ADC map containing the tumor and summated to obtain histograms for entire tumor volume. Calculated histographic parameters included mean ADC (mADC), 5th percentile ADC, 10th percentile ADC, 25th percentile ADC, 50th percentile ADC, 75th percentile ADC (ADC75), 90th percentile ADC (ADC90) and 95th percentile ADC (ADC95), skewness and kurtosis. Histogram parameters were correlated with tumor grade by repeated measures analysis of variance with Tukey-Kramer post hoc comparisons.Results: The mADC, ADC75, ADC90, and ADC95 were significantly higher in G1 tumors (1283 ± 267; 1404 ± 300; 1495 ± 318; 1562 ± 347 × 10(-6) mm(2)/s) compared to G2 (892 ± 390; 952 ± 381; 1036 ± 384; 1072 ± 374 × 10(-6) mm(2)/s) and to G3 tumors (733 ± 225; 864 ± 284; 1008 ± 288; 1152 ± 192 × 10(-6) mm(2)/s) (p value <0.05). Skewness and kurtosis were significantly different between G1 (0.041 ± 0.466; 2.802 ± 0.679) and G3 (1.01 ± 1.140; 5.963 ± 4.008) tumors (p value <0.05). Tumor volume (mL) was significantly higher on G3 (55 ± 15.7) compared to G1 (1.9 ± 2.7) and G2 (4.5 ± 3.6) tumors (p value <0.05). In this small sample size, we did not detect statistically significant parameters between G2 (n = 4) and G3 (n = 3) tumors.Conclusions: Histographic analysis of ADC maps on the basis of the entire tumor volume can be useful in differentiating histologic grades of PNTs. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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