Information in pallidal neurons increases with parkinsonian severity.
Introduction: The motor symptoms of Parkinson's disease (PD) present with pathological neuronal activity in the basal ganglia. Although neuronal firing rate changes in the globus pallidus internus (GPi) and externus (GPe) are reported to underlie the development of PD motor signs, firing rates chang...
| Publicado en: | Parkinsonism & Related Disorders Vol. 21; no. 11; pp. 1355 - 1362 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110661277&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110661277 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13538020 JNO jtl: Parkinsonism & Related Disorders issn: 13538020 maglogo: N pubinfo: dt: Nov2015 vid: 21 iid: 11 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 110661277 110661277 NLM26433544 110661277 10.1016/j.parkreldis.2015.09.045 NLM26433544 PMC4631644 [Available on 11/01/16] 110661277 ppf: 1355 ppct: 7 formats: tig: atl: Information in pallidal neurons increases with parkinsonian severity. aug: au: Dorval, Alan D. Muralidharan, Abirami Jensen, Alicia L. Baker, Kenneth B. Vitek, Jerrold L. affil: Department of Bioengineering, University of Utah, Salt Lake City, UT, USA sug: subj: Parkinson Disease Physiopathology Neurons Physiology Electrophysiology Severity of Illness Indices Basal Ganglia Physiopathology Animal Studies Male Physics Female Models, Biological Primates Funding Source Male Female ab: Introduction: The motor symptoms of Parkinson's disease (PD) present with pathological neuronal activity in the basal ganglia. Although neuronal firing rate changes in the globus pallidus internus (GPi) and externus (GPe) are reported to underlie the development of PD motor signs, firing rates change inconsistently, vary confoundingly with some therapies, and are poor indicators of symptom severity.Methods: We explored the relationship between parkinsonian symptom severity and the effectiveness with which pallidal neurons transmit information. We quantify neuronal entropy and information - alternatives to firing rate and correlations respectively - in and between GPe and GPi neurons using a progressive, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, non-human primate model of PD.Results: Neuronal entropy and symptom severity were not linearly correlated: in both pallidal segments, entropy increased from naive to moderate parkinsonism, but decreased with further progression to the severely parkinsonian condition. In contrast, information transmitted from GPe to GPi increased consistently with symptom severity. Furthermore, antidromic information from GPi to GPe increased substantially with symptom severity. Together, these findings suggest that as parkinsonian severity increases, more and more information enters GPe and GPi from common sources, diminishing the relative importance of the orthodromic GPe to GPi connection.Conclusions: With parkinsonian progression, the direct and indirect pathways lose their independence and start to convey redundant information. We hypothesize that a loss of parallel processing impairs the ability of the network to select and implement motor commands, thus promoting the hypokinetic symptoms of PD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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