Association between Dioxin and Diabetes Mellitus in an Endemic Area of Exposure in Taiwan: A Population-Based Study.
Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM.We recru...
| Publicado en: | Medicine Vol. 94; no. 42; pp. 1 - 7 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Oct2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110664571&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110664571 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: Oct2015 vid: 94 iid: 42 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110664571 110664571 NLM26496286 110664571 10.1097/MD.0000000000001730 NLM26496286 PMC4620805 110664571 ppf: 1 ppct: 6 formats: tig: atl: Association between Dioxin and Diabetes Mellitus in an Endemic Area of Exposure in Taiwan: A Population-Based Study. aug: au: Chien-Yuan Huang Cheng-Long Wu Yi-Ching Yang Jung-Wei Chang Yau-Chang Kuo Ya-Yun Cheng Jin-Shang Wu Ching-Chang Lee How-Ran Guo Huang, Chien-Yuan Wu, Cheng-Long Yang, Yi-Ching Chang, Jung-Wei Kuo, Yau-Chang Cheng, Ya-Yun Wu, Jin-Shang Lee, Ching-Chang Guo, How-Ran affil: Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan sug: subj: Diabetes Mellitus, Type 2 Chemically Induced Environmental Pollutants Adverse Effects Dioxins Adverse Effects Female Male Taiwan Diabetes Mellitus, Type 2 Epidemiology Young Adult Adult Risk Factors Public Health Middle Age Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM.We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We defined DM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis.Of the 2898 participants, 425 patients of DM were identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid = 2.1, 95% confidence interval [95% CI] 1.5-2.9; AOR for ≥64 pg WHO98-TEQDF/g lipid = 3.2, 95% CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women.Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|