Ranitidine in a twice daily triple-therapy regimen for the eradication of Helicobacter pylori.
Objective: To compare the efficacy and safety of ranitidine 300 mg twice daily plus amoxycillin 1000 mg twice daily for 2 weeks (RA2) with ranitidine 300 mg twice daily, amoxycillin 1000 mg twice daily, plus tinidazole 500 mg twice daily for 2 weeks (RAT2) for the eradication of Helicobacter pylori....
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 8; no. 12; pp. 1169 - 1174 |
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| Autores principales: | , , , , , |
| Formato: | clinical trial research randomized controlled trial Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Dec1996
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110687302&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110687302 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Dec1996 vid: 8 iid: 12 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110687302 110687302 NLM8980935 110687302 10.1097/00042737-199612000-00007 NLM8980935 110687302 ppf: 1169 ppct: 5 formats: tig: atl: Ranitidine in a twice daily triple-therapy regimen for the eradication of Helicobacter pylori. aug: au: Drake, Ian M. Axon, Tony T. R. Clark, Adrienne H. E. Drake, I M Axon, T T Clarke, A H affil: From the Centre for Digestive Diseases, The General Infirmary at Leeds, Uxbridge, UK sug: subj: Helicobacter Infections Drug Therapy Helicobacter Pylori Gastrointestinal Agents Therapeutic Use Ranitidine Therapeutic Use Imidazoles Administration and Dosage Middle Age Gastrointestinal Agents Administration and Dosage Imidazoles Therapeutic Use Male Peptic Ulcer Microbiology Penicillins Therapeutic Use Ranitidine Administration and Dosage Drug Administration Schedule Drug Therapy, Combination Penicillins Administration and Dosage Peptic Ulcer Drug Therapy Human Female Gastritis Drug Therapy Amoxicillin Administration and Dosage Gastritis Microbiology Prospective Studies Double-Blind Studies Amoxicillin Therapeutic Use Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Middle Aged: 45-64 years Male Female ab: Objective: To compare the efficacy and safety of ranitidine 300 mg twice daily plus amoxycillin 1000 mg twice daily for 2 weeks (RA2) with ranitidine 300 mg twice daily, amoxycillin 1000 mg twice daily, plus tinidazole 500 mg twice daily for 2 weeks (RAT2) for the eradication of Helicobacter pylori.Design: Prospective, randomized, double-blind, parallel-group study in patients who were H. pylori positive on 13C urea breath test (13C UBT).Setting: Twenty-four UK consultant gastroenterologists entered mostly hospital out-patients.Patients: A total of 232 patients with gastric or duodenal ulceration or endoscopic appearances suggestive of gastritis (160 male, 72 female, mean age 51) were entered following routine endoscopy; 223 were H. pylori positive on 13C UBT. Patients with medical conditions or medications which could interfere with study response or measurements and those at risk of pregnancy were excluded. Two hundred and three patients completed the study.Interventions: Patients underwent endoscopy with biopsy for rapid urease (CLO) test. Those who were positive had a 13C UBT. Patients were randomized to receive RA2 or RAT2. Eradication of H. pylori was assessed by 13C UBT 4 weeks after completion of therapy. Blood was taken for haematological and biochemical screening at the beginning and end of treatment.Main Outcome Measure: H. pylori eradication at least 28 days after end of treatment.Results: In the intention-to-treat sample analysis, H. pylori was eradicated in 78/115 patients (68%) taking RAT2 and 42/108 patients (39%) taking RA2. In the per-protocol sample analysis H. pylori eradication was successful in 68/79 patients (86%) taking RAT2 and 36/71 patients (51%) taking RA2. One hundred and seventeen patients experienced 242 adverse events.Conclusion: Twice daily ranitidine triple therapy is a useful H. pylori eradication regimen. pubtype: Academic Journal doctype: clinical trial research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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