Do patients need to fast for a 13C-urea breath test?
Objective: The 13C-urea breath test (13C-UBT) is a useful non-invasive method of diagnosing Helicobacter pylori infection. One of its limitations, however, is that patients have to fast for 4 h before testing. We have compared the accuracy of a non-fasting 13C-UBT (NF13C-UBT) with a fasting 13C-UBT...
| Published in: | European Journal of Gastroenterology & Hepatology Vol. 9; no. 3; pp. 275 - 278 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Lippincott Williams & Wilkins
Mar1997
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110687337&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110687337 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Mar1997 vid: 9 iid: 3 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 110687337 110687337 NLM9096429 110687337 10.1097/00042737-199703000-00010 NLM9096429 110687337 ppf: 275 ppct: 3 formats: tig: atl: Do patients need to fast for a 13C-urea breath test? aug: au: Moayyedi, Paul Braunholtz, David Heminbrough, Elaine Clough, Michael Tompkins, David S. Mapstone, Nic P. Mason, Su Dowell, Anthony C. Richards, Gerald I.D. Chalmers, Douglas M. Axon, Anthony T. Moayyedi, P Braunholtz, D Heminbrough, E Clough, M Tompkins, D S Mapstone, N P Mason, S Dowell, A C Richards, I D affil: From the 1Centre for Digestive Diseases, Leeds General Infirmary, Great George Street, Leeds, 2Department of Epidemiology and Primary Care, University of Leeds, 3Public Health Laboratory, Leeds, 4Algernon Firth Institute of Pathology, University of Leeds and 5Yorkshire Clinical Trials and Research Unit, Cookridge Hospital, Leeds, UK. sug: subj: Fasting Helicobacter Pylori Helicobacter Infections Diagnosis Breath Tests Methods Urea Crossover Design Gastric Mucosa Metabolism Urease Metabolism Biopsy Sensitivity and Specificity Isotopes Human ab: Objective: The 13C-urea breath test (13C-UBT) is a useful non-invasive method of diagnosing Helicobacter pylori infection. One of its limitations, however, is that patients have to fast for 4 h before testing. We have compared the accuracy of a non-fasting 13C-UBT (NF13C-UBT) with a fasting 13C-UBT (F13C-UBT) test and against a gold standard.Design: An unblinded prospective crossover study.Methods: H. pylori status was assessed by histology, culture and rapid urease test. Patients were defined as H. pylori positive if two or more tests gave a positive result and negative if all tests were negative. H. pylori status was indeterminate if only one test gave a positive result. Following endoscopy patients had a F13C-UBT and then a further NF13C-UBT up to 14 days later after eating two slices of toast with jam or honey and tea or coffee.Results: Of the 222 patients recruited to the study, 123 were gold standard H. pylori positive and 94 were negative with five patients having indeterminate status. Compared to this gold standard the NF13C-UBT had a 98% sensitivity and 96% specificity and the F13C-UBT had a 96% sensitivity and 97% specificity. The NF13C-UBT and F13C-UBT agreed in 217/222 (98%) cases.Conclusion: Relaxation of the fasting state does not reduce the accuracy of the 13C-UBT, making this test more convenient for patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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