Hypodense liver lesions in patients with hepatic steatosis: do we profit from dual-energy computed tomography?
Purpose: To evaluate dual-energy CT (DECT) imaging of hypodense liver lesions in patients with hepatic steatosis, having a high incidence in the general population and among cancer patients receiving chemotherapy.Methods: One hundred and five patients with hepatic steatosis (liver parenchyma <40 HU)...
| Published in: | European Radiology Vol. 25; no. 12; pp. 3567 - 3577 |
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| Main Authors: | , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Dec2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=110814254&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 110814254 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2015 vid: 25 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 110814254 110814254 NLM25981220 110814254 10.1007/s00330-015-3772-6 NLM25981220 110814254 ppf: 3567 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Hypodense liver lesions in patients with hepatic steatosis: do we profit from dual-energy computed tomography? aug: au: Nattenmüller, Johanna Hosch, Waldemar Nguyen, Tri-Thien Skornitzke, Stephan Jöres, Andreas Grenacher, Lars Kauczor, Hans-Ulrich Sommer, Christof Stiller, Wolfram Sommer, Christof M affil: Department of Diagnostic and Interventional Radiology (DIR), University Hospital Heidelberg, Im Neuenheimer Feld 110 69120 Heidelberg Germany sug: subj: Tomography, X-Ray Computed Methods Radiographic Image Interpretation, Computer-Assisted Methods Liver Neoplasms Radiography Fatty Liver Radiography Radiographic Image Enhancement Methods Radiographic Image Enhancement Sensitivity and Specificity Observer Bias Aged Analysis of Variance Prospective Studies Male Female Liver Neoplasms Complications Contrast Media Liver Radiography Fatty Liver Complications Human Aged: 65+ years Male Female ab: Purpose: To evaluate dual-energy CT (DECT) imaging of hypodense liver lesions in patients with hepatic steatosis, having a high incidence in the general population and among cancer patients receiving chemotherapy.Methods: One hundred and five patients with hepatic steatosis (liver parenchyma <40 HU) underwent contrast-enhanced DECT with reconstruction of pure iodine (PI), optimum contrast (OC), 80 kVp, and 120 kVp-equivalent data sets. Image noise (IN), lesion to liver signal to noise (SNR) and contrast to noise (CNR) ratios were quantitatively analysed; image quality was rated on a 5-point scale (1, excellent; 2, good; 3, fair; 4, poor; 5, non-diagnostic) by two independent reviewers.Results: In 21 patients with hypodense liver lesions, IN was lowest in PI followed by 120 kVp-equivalent and OC, and highest in 80 kVp. SNR was highest in PI (1.30), followed by 120 kVp-equivalent (0.72) and 80 kVp (0.63), and lowest in OC (0.55). CNR was highest in 120 kVp-equivalent (4.95), followed by OC (4.55) and 80 kVp (4.14), and lowest in PI (3.63). The 120 kVp-equivalent series exhibited best overall qualitative image score (1.88), followed by OC (1.98), 80 kVp (3.00) and PI (3.67).Conclusion: In our study, the 120 kVp-equivalent series was best suited for visualization of hypodense lesions within steatotic liver parenchyma, while using DECT currently seems to offer no additional diagnostic advantage.Key Points: • Hepatic steatosis has high incidence in the general population and following chemotherapy. • Hypodense liver lesions can be obscured by steatotic liver parenchyma in CT. • Low kV p -CT shows no advantage in detecting hypodense lesions in steatotic livers. • Additional DECT image information does not improve visualization of hypodense lesions in steatosis. • 120 kV p -equivalent imaging yields best quantitative and qualitative image analysis results. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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