Simplification of a pharmacokinetic model for red blood cell methotrexate disposition.
Purpose: A pharmacokinetic (PK) model is available for describing the time course of the concentrations of methotrexate (MTX or MTXGlu) and its active polyglutamated metabolites (MTXGlu) in red blood cells (RBCs). In this study, we aimed to simplify the MTX PK model and to optimise the blood samplin...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 71; no. 12; pp. 1509 - 1517 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |