Short-term glucagon stimulation test of C-peptide effect on glucose utilization in patients with type 1 diabetes mellitus.
This work aimed to evaluate the use of a four-point glucagon stimulation test of C-peptide effect on glucose utilization in type 1 diabetic patients using a new mathematical model. A group of 32 type 1 diabetic patients and a group of 10 healthy control subjects underwent a four-point glucagon stimu...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 53; no. 12; pp. 1361 - 1370 |
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| Autores principales: | , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111243899&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111243899 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Dec2015 vid: 53 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 111243899 111243899 NLM26607818 111243899 10.1007/s11517-015-1416-2 NLM26607818 111243899 ppf: 1361 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Short-term glucagon stimulation test of C-peptide effect on glucose utilization in patients with type 1 diabetes mellitus. aug: au: Mojto, Viliam Rausova, Zuzana Chrenova, Jana Dedik, Ladislav affil: IIIrd Department of Internal Medicine, Derer's University Hospital, Limbova 5 833 05 Bratislava Slovakia sug: subj: Diabetes Mellitus, Type 1 Metabolism Blood Glucose Metabolism C-Peptide Metabolism Glucagon Metabolism Adult Glucose Tolerance Test Case Control Studies Glucagon Administration and Dosage Male Female Young Adult Models, Statistical Human Adult: 19-44 years Male Female ab: This work aimed to evaluate the use of a four-point glucagon stimulation test of C-peptide effect on glucose utilization in type 1 diabetic patients using a new mathematical model. A group of 32 type 1 diabetic patients and a group of 10 healthy control subjects underwent a four-point glucagon stimulation test with blood sampling at 0, 6, 15 and 30 min after 1 mg glucagon bolus intravenous administration. Pharmacokinetic and pharmacokinetic/pharmacodynamic models of C-peptide effect on glucose utilization versus area under curve (AUC) were used. A two-sample t test and ANOVA with Bonferroni correction were used to test the significance of differences between parameters. A significant difference between control and patient groups regarding the coefficient of whole-body glucose utilization and AUC C-peptide/AUC glucose ratio (p ≪ 0.001 and p = 0.002, respectively) was observed. The high correlation (r = 0.97) between modeled coefficient of whole-body glucose utilization and numerically calculated AUC C-peptide/AUC glucose ratio related to entire cohort indicated the stability of used method. The short-term four-point glucagon stimulation test allows the numerically calculated AUC C-peptide/AUC glucose ratio and/or the coefficient of whole-body glucose utilization calculated from model to be used to diagnostically identify type 1 diabetic patients. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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