Proof of principle: Transformation approach alters caudate nucleus volume and structure-function associations.
Brain magnetic resonance image (MRI) registration alters structure orientation, size, and/or shape. To determine whether linear registration methods (image transformation to 6, 9, and 12° of freedom) alter structural volume and cognitive associations, we examined transformation alterations to the ca...
| Publicado en: | Brain Imaging & Behavior Vol. 9; no. 4; pp. 744 - 754 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111244199&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111244199 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2015 vid: 9 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 111244199 111244199 NLM25413122 111244199 10.1007/s11682-014-9332-x NLM25413122 PMC4440856 [Available on 12/01/16] 111244199 ppf: 744 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Proof of principle: Transformation approach alters caudate nucleus volume and structure-function associations. aug: au: Schwab, Nadine Tanner, Jared Nguyen, Peter Schmalfuss, Ilona Bowers, Dawn Okun, Michael Price, Catherine Schwab, Nadine A Tanner, Jared J Nguyen, Peter T Schmalfuss, Ilona M Price, Catherine C affil: Department of Clinical and Health Psychology, University of Florida, 1225 Center Drive Gainesville 32611 USA sug: subj: Magnetic Resonance Imaging Methods Parkinson Disease Psychosocial Factors Image Processing, Computer Assisted Methods Parkinson Disease Pathology Basal Ganglia Pathology Cognition Neuropsychological Tests Male Middle Age Aged Female Body Weights and Measures Funding Source Human Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Brain magnetic resonance image (MRI) registration alters structure orientation, size, and/or shape. To determine whether linear registration methods (image transformation to 6, 9, and 12° of freedom) alter structural volume and cognitive associations, we examined transformation alterations to the caudate nucleus within individuals diagnosed with Parkinson's disease (PD) and demographically matched non-PD peers. Volumes from native and six were expected be significantly different from 9 and 12° of freedom methods. Caudate nucleus volumes were expected to be associated with measures of processing speed and mental flexibility, but the strength of the association based on transformation approach was unknown. MRI brain scans from individuals with Parkinson's disease (n = 40) and age-matched controls (n = 40) were transformed using 6, 9, and 12° of freedom to an average brain template. Correlations controlling for total intracranial volume assessed expected structural-behavioral associations. Volumetric: Raw 9 and 12° transformed volumes were significantly larger than native and 6° volumes. Only 9 and 12° volumes revealed group differences with PD less than controls. Intracranial volume considerations were essential for native and 6° between group comparisons. Structural-Behavioral: The 9 and 12° caudate nucleus volume transformations revealed the expected brain-behavioral associations. Linear registration techniques alter volumetric and cognitive-structure associations. The study highlights the need to communicate transformation approach and group intracranial volume considerations. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|