Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome.
Metabolic Syndrome (MetS), the clustering of obesity, high blood pressure, and disordered glucose and lipid/lipoprotein metabolism within a single individual, is associated with poorer cognitive function. It has been hypothesized that cognitive impairment in MetS occurs primarily within the context...
| Published in: | Brain Imaging & Behavior Vol. 9; no. 4; pp. 737 - 744 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Dec2015
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111244200&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111244200 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2015 vid: 9 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 111244200 111244200 NLM25376331 111244200 10.1007/s11682-014-9330-z NLM25376331 PMC4424190 [Available on 12/01/16] 111244200 ppf: 737 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome. aug: au: Kaur, Sonya Gonzales, Mitzi Eagan, Danielle Goudarzi, Katyoon Tanaka, Hirofumi Haley, Andreana Kaur, Sonya S Gonzales, Mitzi M Eagan, Danielle E Haley, Andreana P affil: Department of Psychology, The University of Texas at Austin, 108 E. Dean Keeton, Stop A8000 Austin 78712 USA sug: subj: Cerebral Cortex Pathology Metabolic Syndrome X Pathology Metabolic Syndrome X Immunology Enzyme-Linked Immunosorbent Assay Female Magnetic Resonance Imaging Blood Chemical Analysis Adult Neuropsychological Tests Risk Factors Immunity Body Weights and Measures Middle Age Male Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Metabolic Syndrome (MetS), the clustering of obesity, high blood pressure, and disordered glucose and lipid/lipoprotein metabolism within a single individual, is associated with poorer cognitive function. It has been hypothesized that cognitive impairment in MetS occurs primarily within the context of inflammation. MetS risk factors are also associated with thinning of the cerebral cortex. However, the mechanisms by which MetS and inflammation affect the brain are poorly understood. The present study used statistical mediation to examine the relationship between MetS risk factors, cortical thickness in a priori regions of interest (ROIs) and inflammation. ROIs were chosen from the previous literature. Forty-three adults between the ages of 40 and 60 years underwent a health screen, neuropsychological testing and structural magnetic resonance imaging. Serum levels of pro-inflammatory markers (interleukin 1, interleukin 2, interleukin 6 and C-Reactive Protein) were measured using enzyme-linked immunosorbent assays. A higher number of MetS risk factors were associated with thinning in the inferior frontal ROI (β = -0.35, p = 0.019) as well as higher levels of serum interleukin 2 (β = 0.31, p = 0.04). A higher level of serum interleukin 2 was also associated with reduced thickness in the inferior frontal gyrus (β = -0.41, p = 0.013). After accounting for the effects of interleukin 2, the number of MetS risk factors was no longer associated with cortical thickness in the inferior frontal gyrus indicating successful statistical mediation. The results indicate a potentially important role for inflammation in linking MetS to cortical thinning and cognitive vulnerability. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|