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Posteromedial hyperactivation during episodic recognition among people with memory decline: findings from the WRAP study.

Episodic memory decline is one of the earliest preclinical symptoms of AD, and has been associated with an upregulation in the BOLD response in the prodromal stage (e.g. MCI) of AD. In a previous study, we observed upregulation in cognitively normal (CN) subjects with subclinical episodic memory dec...

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Published in:Brain Imaging & Behavior Vol. 9; no. 4; pp. 690 - 703
Main Authors: Nicholas, Christopher, Okonkwo, Ozioma, Bendlin, Barbara, Oh, Jennifer, Asthana, Sanjay, Rowley, Howard, Hermann, Bruce, Sager, Mark, Johnson, Sterling, Nicholas, Christopher R, Okonkwo, Ozioma C, Bendlin, Barbara B, Oh, Jennifer M, Rowley, Howard A, Sager, Mark A, Johnson, Sterling C
Format: diagnostic images research tables/charts Journal Article
Published: Springer Nature Dec2015
Online Access:View this record in EBSCOhost
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      dt: Dec2015
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      pub: Springer Nature
      place: New York, New York
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        atl: Posteromedial hyperactivation during episodic recognition among people with memory decline: findings from the WRAP study.
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          Nicholas, Christopher
          Okonkwo, Ozioma
          Bendlin, Barbara
          Oh, Jennifer
          Asthana, Sanjay
          Rowley, Howard
          Hermann, Bruce
          Sager, Mark
          Johnson, Sterling
          Nicholas, Christopher R
          Okonkwo, Ozioma C
          Bendlin, Barbara B
          Oh, Jennifer M
          Rowley, Howard A
          Sager, Mark A
          Johnson, Sterling C
        affil: Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison USA
      sug:
        subj:
          Recognition (Psychology)
          Memory
          Brain Physiopathology
          Memory Disorders Physiopathology
          Cognition Disorders Physiopathology
          Cognition Disorders Pathology
          Magnetic Resonance Imaging
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          Cerebrovascular Circulation Physiology
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          Data Collection
          Memory Disorders Pathology
          Oxygen Blood
          Body Weights and Measures
          Gray Matter Pathology
          Gray Matter Physiopathology
          Brain Mapping
          Adult
          Brain Pathology
          Prospective Studies
          Neuropsychological Tests
          Male
          Funding Source
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          Middle Aged: 45-64 years
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          Adult: 19-44 years
          Female
          Male
      ab: Episodic memory decline is one of the earliest preclinical symptoms of AD, and has been associated with an upregulation in the BOLD response in the prodromal stage (e.g. MCI) of AD. In a previous study, we observed upregulation in cognitively normal (CN) subjects with subclinical episodic memory decline compared to non-decliners. In light of this finding, we sought to determine if a separate cohort of Decliners will show increased brain activation compared to Stable subjects during episodic memory processing, and determine whether the BOLD effect was influenced by cerebral blood flow (CBF) or gray matter volume (GMV). Individuals were classified as a "Decliner" if scores on the Rey Auditory Verbal Learning Test (RAVLT) consistently fell ≥ 1.5 SD below expected intra- or inter-individual levels. FMRI was used to compare activation during a facial recognition memory task in 90 Stable (age = 59.1) and 34 Decliner (age = 62.1, SD = 5.9) CN middle-aged adults and 10 MCI patients (age = 72.1, SD = 9.4). Arterial spin labeling and anatomical T1 MRI were used to measure resting CBF and GMV, respectively. Stables and Decliners performed similarly on the episodic recognition memory task and significantly better than MCI patients. Compared to Stables, Decliners showed increased BOLD signal in the left precuneus on the episodic memory task that was not explained by CBF or GMV, familial AD risk factors, or neuropsychological measures. These findings suggest that subtle changes in the BOLD signal reflecting altered neural function may be a relatively early phenomenon associated with memory decline.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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