Parametric response mapping of dynamic CT for predicting intrahepatic recurrence of hepatocellular carcinoma after conventional transcatheter arterial chemoembolization.
Objectives: The aim of our study was to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM) for prediction of intrahepatic recurrence of hepatocellular carcinoma (HCC) treated with conventional transcatheter arterial chemoembolization (TACE).Metho...
| Publicado en: | European Radiology Vol. 26; no. 1; pp. 225 - 235 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111289942&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111289942 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2016 vid: 26 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 111289942 111289942 NLM25991485 111289942 10.1007/s00330-015-3825-x NLM25991485 111289942 ppf: 225 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Parametric response mapping of dynamic CT for predicting intrahepatic recurrence of hepatocellular carcinoma after conventional transcatheter arterial chemoembolization. aug: au: Choi, Seung Kim, Jonghoon Seo, Jongbum Kim, Hyung Lee, Jong-min Park, Hyunjin Choi, Seung Joon Kim, Hyung Sik affil: Department of Radiology, Gachon University Gil Hospital, Incheon Korea sug: subj: Antineoplastic Agents Administration and Dosage Carcinoma, Hepatocellular Radiography Liver Neoplasms Radiography Chemoembolization, Therapeutic Methods Neoplasm Recurrence, Local Radiography Catheterization, Peripheral Methods Tomography, X-Ray Computed Methods Aged Neoplasm Recurrence, Local Prevention and Control Liver Neoplasms Drug Therapy Adult Retrospective Design Injections, Intraarterial Carcinoma, Hepatocellular Therapy Female Male Middle Age Human Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: The aim of our study was to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM) for prediction of intrahepatic recurrence of hepatocellular carcinoma (HCC) treated with conventional transcatheter arterial chemoembolization (TACE).Methods: This retrospective study was approved by the IRB. We recruited 55 HCC patients who achieved complete remission (CR) after TACE and received longitudinal multiphasic liver computed tomography (CT). The patients fell into two groups: the recurrent tumour group (n = 29) and the non-recurrent tumour group (n = 26). We applied the PRM analysis to see if this technique could distinguish between the two groups. The results of the PRM analysis were incorporated into a prediction algorithm. We retrospectively removed data from the last time point and attempted to predict the response to therapy of the removed data.Results: The PRM analysis was able to distinguish between the non-recurrent and recurrent groups successfully. The prediction algorithm detected response to therapy with an area under the curve (AUC) of 0.76, while the manual approach had AUC 0.64.Conclusions: Adopting PRM analysis can potentially distinguish between recurrent and non-recurrent HCCs and allow for prediction of response to therapy after TACE.Key Points: Parametric response mapping (PRM) could help assess patients with recurrent HCCs after TACE. Parametric response mapping could direct patients to individualized therapy. Longitudinal CT images were analyzed with advanced image analysis method. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|