Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial.
Ethnopharmacological relevance A honey based formulation from Nigella sativa L. (N. sativa) has been used in Traditional Persian Medicine for upper gastrointestinal symptoms. Considering the traditional use of this formulation and its ingredients known pharmacologic effects, this study aimed to eval...
| Publicado en: | Journal of Ethnopharmacology Vol. 175; pp. 147 - 153 |
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| Autores principales: | , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Elsevier B.V.
Dec2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111320240&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111320240 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03788741 3MS jtl: Journal of Ethnopharmacology issn: 03788741 maglogo: N pubinfo: dt: Dec2015 vid: 175 pid: 1004 pub: Elsevier B.V. artinfo: ui: 111320240 111320240 111320240 10.1016/j.jep.2015.09.022 111320240 ppf: 147 ppct: 6 formats: tig: atl: Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. aug: au: Mohtashami, Reza Fallah Huseini, Hasan Heydari, Mojtaba Amini, Mohsen Sadeqhi, Zainab Ghaznavi, Habib Mehrzadi, Saeed affil: Medicine Quran and hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran sug: subj: Honey Therapeutic Use Plants, Medicinal Seeds Plant Extracts Therapeutic Use Dyspepsia Therapy Human Alternative Therapies Randomized Controlled Trials Random Assignment Double-Blind Studies Descriptive Statistics Endoscopy, Gastrointestinal Pretest-Posttest Design Helicobacter Infections Diagnosis Short Form-36 Health Survey (SF-36) Clinical Assessment Tools Statistical Significance P-Value ab: Ethnopharmacological relevance A honey based formulation from Nigella sativa L. (N. sativa) has been used in Traditional Persian Medicine for upper gastrointestinal symptoms. Considering the traditional use of this formulation and its ingredients known pharmacologic effects, this study aimed to evaluate the efficacy and safety of N. sativa seed oil mixed with honey in treatment of patients with functional dyspepsia. Methods and materials Seventy patients diagnosed with functional dyspepsia according to ROME III criteria and confirmed by upper gastrointestinal endoscopy were selected to receive a traditional honey based formulation of N. sativa (5 ml N. sativa oil orally daily) or placebo for 8 weeks in a double-blind randomized placebo-controlled clinical trial using a parallel design with a 1:1 allocation ratio. Patients were evaluated prior to and following 8 weeks of the intervention in terms of the Hong Kong index of dyspepsia severity, presence of Helicobacter pylori infection based on urease test, scores in different domains of short form (SF-36) health survey, and any observed adverse events. Results The mean scores of Hong Kong index of dyspepsia severity sores and the rate of H. pylori infection were significantly lower in the N. sativa group comparing the placebo group after the intervention ( P <0.001). No serious adverse event was reported. Conclusion This study showed that adjuvant supplementation of honey based formulation of N. sativa can cause significant symptomatic improvement of patients with functional dyspepsia whom received the standard anti-secretory therapy. The results should be investigated further in studies with longer duration and larger sample size. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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