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Type of dyslipidemia and achievement of the LDL-cholesterol goal in chronic kidney disease patients at the University Hospital.

Background: Chronic kidney disease (CKD) has been defined as a coronary artery disease risk equivalent. Therefore, the current guideline has been recommended for CKD patients to reach and maintain a low-density lipoprotein-cholesterol (LDL-C) goal of less than 100 mg/dL. However, the data regarding...

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Published in:Vascular Health & Risk Management Vol. 11; pp. 563 - 568
Main Authors: Sangsawang, Tamon, Sriwijitkamol, Apiradee
Format: research tables/charts Journal Article
Published: Dove Medical Press Ltd Nov2015
Online Access:View this record in EBSCOhost
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      dt: Nov2015
      vid: 11
      pid: 45064
      pub: Dove Medical Press Ltd
      place: Auckland, <Blank>
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        atl: Type of dyslipidemia and achievement of the LDL-cholesterol goal in chronic kidney disease patients at the University Hospital.
      aug:
        au:
          Sangsawang, Tamon
          Sriwijitkamol, Apiradee
        affil: Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
      sug:
        subj:
          Antilipemic Agents Therapeutic Use
          Lipoproteins, LDL Cholesterol Blood
          Hyperlipidemia Drug Therapy
          Renal Insufficiency, Chronic Epidemiology
          Academic Medical Centers
          Middle Age
          Risk Factors
          Hyperlipidemia Blood
          Prevalence
          Hyperlipidemia Epidemiology
          Renal Insufficiency, Chronic Diagnosis
          Male
          Aged
          Time Factors
          Retrospective Design
          Treatment Outcomes
          Female
          Hyperlipidemia Diagnosis
          Aged, 80 and Over
          Thailand
          Human
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Background: Chronic kidney disease (CKD) has been defined as a coronary artery disease risk equivalent. Therefore, the current guideline has been recommended for CKD patients to reach and maintain a low-density lipoprotein-cholesterol (LDL-C) goal of less than 100 mg/dL. However, the data regarding the achievement of LDL-C goal in these patients is lacking.Objective: This study was conducted to evaluate the types of dyslipidemia affecting patients with CKD stages 3 and 4 and to determine whether these patients achieved LDL-C goal.Methods: We performed a retrospective chart review of patients with CKD stage 3 or 4 and dyslipidemia who were followed-up at Siriraj Hospital between October 2011 and September 2012.Results: In total, 150 patients with CKD stage 3 or 4 and dyslipidemia were recruited. The mean age was 72±10 years, and the body mass index was 25.6±4 kg/m(2); 60% had CKD stage 3 with an estimated glomerular filtration rate of 34±12 mL/min/1.73 m(2), and 54% had type 2 diabetes. The percentage of patients with hypercholesterolemia was 78%, hypertriglyceridemia 54%, and low high-density lipoprotein-C 36%. Of these, 52% had mixed hyperlipidemia. Statin treatment was prescribed to 87% of the patients, of which only 31.3% achieved the LDL-C goal according to the National Cholesterol Education Program and the European Society of Cardiology/European Atherosclerosis Society recommendations. Patients who did not achieve the LDL-C goal had a higher cholesterol level at diagnosis and higher prevalence of type 2 diabetes and stroke than those who achieved it.Conclusion: Two-thirds of CKD patients with hyperlipidemia had mixed hyperlipidemia. Despite the high frequency of statin treatment, only one-third of patients with CKD achieved the LDL-C goal. Thus, a developmental plan for the management of dyslipidemia in patients with CKD should be implemented to increase their achievement of the LDL-C goal.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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