Helicobacter pylori infection associated with type 2 diabetic nephropathy in patients with dyspeptic symptoms.
Aims: The aim of this conventional case-control study was to investigate the prevalence and relationship between Helicobacter pylori infection in type 2 diabetes mellitus (DM) and diabetic nephropathy (DN).Methods: A total of 241 type 2 DM patients and 69 non-diabetic subjects with dyspeptic symptom...
| Publicado en: | Diabetes Research & Clinical Practice Vol. 110; no. 3; pp. 328 - 335 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Dec2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111440665&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111440665 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01688227 3K1 jtl: Diabetes Research & Clinical Practice issn: 01688227 maglogo: N pubinfo: dt: Dec2015 vid: 110 iid: 3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 111440665 111440665 NLM26547504 111440665 10.1016/j.diabres.2015.09.008 NLM26547504 111440665 ppf: 328 ppct: 7 formats: tig: atl: Helicobacter pylori infection associated with type 2 diabetic nephropathy in patients with dyspeptic symptoms. aug: au: Zhou, Fei Zhong, Xiaoqin Chen, Jingbo Li, Chunguo Shang, Ming Jiang, Cheng Yang, Hairong Zhao, Weidong Liu, Liqiu affil: Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, PR China sug: subj: Diabetes Mellitus, Type 2 Complications Diabetic Nephropathies Complications Helicobacter Infections Complications Case Control Studies Diabetic Nephropathies Microbiology Adult Interleukins Blood Tumor Necrosis Factor Blood Albuminuria Complications Male Female Middle Age Diabetes Mellitus, Type 2 Microbiology Prevalence Helicobacter Pylori Albuminuria Microbiology Human Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Aims: The aim of this conventional case-control study was to investigate the prevalence and relationship between Helicobacter pylori infection in type 2 diabetes mellitus (DM) and diabetic nephropathy (DN).Methods: A total of 241 type 2 DM patients and 69 non-diabetic subjects with dyspeptic symptoms were enrolled in the study. Gastroduodenal lesions were observed by gastrointestinal endoscopy and the presence of H. pylori was identified by rapid urease test and serum IgG antibodies to H. pylori. According to the urinary albumin excretion rate (UAE), patients were classified into diabetes mellitus group (DM group, with UAE <30 mg/24h); diabetic nephropathy group 1 (DN group 1, with UAE 30 mg/24 h to <300 mg/24 h); and diabetic nephropathy group 2 (DN group 2 ≥ 300 mg/24 h). The 69 non-diabetic subjects were used as control group. The serum levels of inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-8 were determined using ELISA.Results: The prevalence of H. pylori infection in DN group 1 and DN group 2 was 45/72 (62.5%) and 34/53 (64.15%), respectively, which was significantly higher than in control [28/65 (43.1%)] and DM groups [42.9% (27/63)]. No significant differences of H. pylori prevalence were detected between DN groups as well as DM and control groups. Interestingly, in both DN groups, higher levels of IL-8, TNF-α and urinary albumin excretion rate were found in H. pylori positive subjects.Conclusions: Diabetic nephropathy patients are more susceptible to H. pylori infection. Our data support an association between H. pylori infection and diabetic nephropathy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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