Two-week Triple Therapy has a Higher Helicobacter pylori Eradication Rate Than 1-week Therapy: A Single-center Randomized Study.
Background and Aim: To evaluate a high effective and practical regimen for the eradication of Helicobacter pylori infection. Patients and Methods: The 298 patients with H. pylori infection, diagnosed by biopsies performed during the endoscopy, were randomized into two groups. Group 1: Treated for on...
| Publicado en: | Saudi Journal of Gastroenterology Vol. 21; no. 6; pp. 355 - 360 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Nov/Dec2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111491816&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111491816 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13193767 322P jtl: Saudi Journal of Gastroenterology issn: 13193767 maglogo: N pubinfo: dt: Nov/Dec2015 vid: 21 iid: 6 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 111491816 111491816 111491816 10.4103/1319-3767.170951 111491816 ppf: 355 ppct: 5 formats: tig: atl: Two-week Triple Therapy has a Higher Helicobacter pylori Eradication Rate Than 1-week Therapy: A Single-center Randomized Study. aug: au: Jiaofeng Wang Gansheng Zhang Xiaona Hu Ye Liu Zhijun Bao Yiqin Huang affil: Department of Geriatrics, Huadong Hospital, Shanghai, China sug: subj: Helicobacter Infections Drug Therapy Omeprazole Therapeutic Use Amoxicillin Therapeutic Use Clarithromycin Therapeutic Use Randomized Controlled Trials Human Biopsy Endoscopy Omeprazole Administration and Dosage Amoxicillin Administration and Dosage Clarithromycin Administration and Dosage Breath Tests Treatment Outcomes Helicobacter Infections Diagnosis Drug Combinations Urease ab: Background and Aim: To evaluate a high effective and practical regimen for the eradication of Helicobacter pylori infection. Patients and Methods: The 298 patients with H. pylori infection, diagnosed by biopsies performed during the endoscopy, were randomized into two groups. Group 1: Treated for one week with a combination of omeprazole, amoxicillin, and clarithromycin (OAC), named by OAC-1 group (n Group= 143); Group 2: OAC-2 group (n = 155) treated for two weeks with OAC. The OAC=155)-1 group was treated with triple therapy of omeprazole 20 mg, amoxicillin 1000 mg, and clarithromycin 500 mg bid for 1 week. OAC-2 group was treated likewise, but for two weeks. A 13C-urea breath test was used to monitor H. pylori after four to eight weeks following therapy. Results: The eradication of infection was 55% and 68% in the OAC-1 and OAC-2 groups, respectively. Moreover, the eradication rates in the two groups were 63% and 75%, respectively. Compared with the OAC-1 group, the efficacy of treatment in the OAC-2 group is significantly higher (P < 0.05). Conclusion: Two-week OAC regimen yields a higher eradication rate of H. pylori, which might be a practical regimen for the eradication of H. pylori. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|