Primary Antibiotic Resistance to Helicobacter pylori Strains Isolated From Children in Northern Iran: A Single Center Study.
Background: Initial resistance to antibiotics is the main reason for the failure of Helicobacter pylori (H. pylori) eradication in children. Objectives: As we commonly face high antibiotic resistance rates in children, we aimed to determine the susceptibility of H. pylori to common antibiotics. Pati...
| Publicado en: | Iranian Journal of Pediatrics Vol. 25; no. 6; pp. 1 - 5 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Brieflands
Dec2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111511479&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111511479 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082142 5DI1 jtl: Iranian Journal of Pediatrics issn: 20082142 maglogo: N pubinfo: dt: Dec2015 vid: 25 iid: 6 pid: 69510 pub: Brieflands place: , <Blank> artinfo: ui: 111511479 111511479 111511479 10.5812/ijp.2661 111511479 ppf: 1 ppct: 4 formats: tig: atl: Primary Antibiotic Resistance to Helicobacter pylori Strains Isolated From Children in Northern Iran: A Single Center Study. aug: au: Maleknejad, Shohreh Mojtahedi, Ali Safaei-Asl, Afshin Taghavi, Zeinab Kazemnejad, Ehsan affil: Department of Pediatrics, 17th Shahrivar Hospital, Guilan University of Medical Sciences, Rasht, IR Iran sug: subj: Drug Resistance, Microbial Helicobacter Infections In Infancy and Childhood Staining and Labeling Human Cross Sectional Studies In Vitro Studies Infant, Newborn Infant Child, Preschool Child Adolescence Peptic Ulcer Endoscopy, Gastrointestinal Biopsy Stomach Analysis Duodenum Analysis Microbial Culture and Sensitivity Tests Sensitivity and Specificity Metronidazole Therapeutic Use Amoxicillin Therapeutic Use Clarithromycin Therapeutic Use Nitrofurans Therapeutic Use Azithromycin Therapeutic Use Tetracycline Therapeutic Use Prevalence Iran Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years ab: Background: Initial resistance to antibiotics is the main reason for the failure of Helicobacter pylori (H. pylori) eradication in children. Objectives: As we commonly face high antibiotic resistance rates in children, we aimed to determine the susceptibility of H. pylori to common antibiotics. Patients and Methods: In this cross-sectional in vitro study, 169 children younger than 14 years with clinical diagnosis of peptic ulcer underwent upper gastrointestinal endoscopy. Biopsy specimens from stomach and duodenum were cultured. In isolated colonies, tests of catalase, urease, and oxidase as well as gram staining were performed. After confirming the colonies as H. pylori, the antibiogram was obtained using disk diffusion method. Results: Culture for H. pylori was positive in 12.3% of the specimens, urease test in 21.3%, serological test in 18.9% and stool antigen test was positive in 21.9%. We could show high specificity but moderate sensitivity of both histological and H. pylori stool antigen tests to detect H. pylori. The overall susceptibility to metronidazole was 42.9%, amoxicillin 95.2%, clarithromycin 85.7%, furazolidone 61.9%, azithromycin 81.0%, and tetracycline 76.2% with the highest resistance to metronidazole and the lowest to clarithromycin. Conclusions: In our region, there is high resistance of H. pylori to some antibiotics including metronidazole and furazolidone among affected children. To reduce the prevalence of this antibiotic resistance, more controlled use of antibiotics should be considered in children. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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