Corpus Callosum Diffusion and Connectivity Features in High Functioning Subjects With Pyridoxine-Dependent Epilepsy.
Background: In this observational study, white matter structure, functional magnetic resonance imaging (fMRI) task-based responses, and functional connectivity were assessed in four subjects with high functioning pyridoxine-dependent epilepsy and age-matched control subjects.Methods: Four male subje...
| Publicado en: | Pediatric Neurology Vol. 54; pp. 43 - 49 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jan2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111741009&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111741009 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08878994 JNS jtl: Pediatric Neurology issn: 08878994 maglogo: N pubinfo: dt: Jan2016 vid: 54 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 111741009 111741009 NLM26547255 111741009 10.1016/j.pediatrneurol.2015.09.012 NLM26547255 111741009 ppf: 43 ppct: 6 formats: tig: atl: Corpus Callosum Diffusion and Connectivity Features in High Functioning Subjects With Pyridoxine-Dependent Epilepsy. aug: au: Poliachik, Sandra L. Friedman, Seth D. Poliakov, Andrew V. Budech, Christopher B. Ishak, Gisele E. Shaw, Dennis W.W. Jr.,Gospe, Sidney M. Gospe, Sidney M Jr affil: Department of Radiology, Seattle Children's Hospital, Seattle Washington sug: subj: Telencephalon Pathology Epilepsy Pathology Epilepsy Physiopathology Telencephalon Physiopathology Middle Age Magnetic Resonance Imaging Relaxation Neural Pathways Pathology Adult Brain Physiopathology Neural Pathways Physiopathology Brain Pathology Severity of Illness Indices Young Adult Male Mental Processes Neuropsychological Tests Human Middle Aged: 45-64 years Adult: 19-44 years Male ab: Background: In this observational study, white matter structure, functional magnetic resonance imaging (fMRI) task-based responses, and functional connectivity were assessed in four subjects with high functioning pyridoxine-dependent epilepsy and age-matched control subjects.Methods: Four male subjects with pyridoxine-dependent epilepsy (mean age 31 years 8 months, standard deviation 12 years 3 months) and age-matched control subjects (32 years 4 months, standard deviation 13 years) were recruited to participate in the study. Diffusion tensor data were collected and postprocessed in Functional Magnetic Resonance Imaging of the Brain Software Library to quantify corpus callosum tracts as a means to assess white matter structure. Task-based fMRI data were collected and Functional Magnetic Resonance Imaging of the Brain Software Library used to assess task response. The fMRI resting-state data were analyzed with the functional connectivity toolbox Conn to determine functional connectivity.Results: Subjects with high functioning pyridoxine-dependent epilepsy retained structural white matter connectivity compared with control subjects, despite morphologic differences in the posterior corpus callosum. fMRI task-based results did not differ between subjects with pyridoxine-dependent epilepsy and control subjects; functional connectivity as measured with resting-state fMRI was lower in subjects with pyridoxine-dependent epilepsy for several systems (memory, somatosensory, auditory).Conclusion: Although corpus callosum morphology is diminished in the posterior portions, structural connectivity was retained in subjects with pyridoxine-dependent epilepsy, while functional connectivity was diminished for memory, somatosensory, and auditory systems. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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