Neuropsychological evaluation and parental assessment of behavioral and motor difficulties in children with neurofibromatosis type 1.
Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder, with large inter and intrafamilial clinical variability and uncertain prognosis. In children with NF1 cognitive disorders, learning difficulties and behavioral problems are common. The present study aims to establish the n...
| Publicado en: | Research in Developmental Disabilities Vol. 48; pp. 220 - 231 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
Jan2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=111878506&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 111878506 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08914222 JJZ jtl: Research in Developmental Disabilities issn: 08914222 maglogo: N pubinfo: dt: Jan2016 vid: 48 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 111878506 111878506 NLM26625207 111878506 10.1016/j.ridd.2015.11.010 NLM26625207 111878506 ppf: 220 ppct: 11 formats: tig: atl: Neuropsychological evaluation and parental assessment of behavioral and motor difficulties in children with neurofibromatosis type 1. aug: au: Coutinho, V. Kemlin, I. Dorison, N. Billette de Villemeur, T. Rodriguez, D. Dellatolas, G. affil: APHP, GHUEP, Hôpital Trousseau, Service de Neuropédiatrie, 26, avenue Dr. Netter, 75012 Paris, France sug: subj: Learning Disorders Diagnosis Neurofibromatosis 1 Psychosocial Factors Motor Skills Learning Disorders Psychosocial Factors Neurofibromatosis 1 Diagnosis Neurofibromatosis 1 Physiopathology Behavioral Symptoms Diagnosis Parents Psychosocial Factors Neuropsychological Tests Child Reproducibility of Results Female Adolescence Male Human Child: 6-12 years Adolescent: 13-18 years Female Male ab: Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder, with large inter and intrafamilial clinical variability and uncertain prognosis. In children with NF1 cognitive disorders, learning difficulties and behavioral problems are common. The present study aims to establish the neuropsychological and behavioral profiles of 78 patients with NF1, aged between 5 and 18 years, and to examine the relationship between these profiles and the transmission of NF1 (sporadic vs. familial), clinical manifestations, and environmental factors. We used several questionnaires completed by parents and neuropsychological tests. The results confirmed specific neuropsychological disabilities in children with NF1, especially involving visuospatial and fine motor skills, learning difficulties and behavioral problems. Cognitive difficulties were significantly more frequent in patients with familial than in those with sporadic NF1. All parental questionnaires were correlated with each other, but parental reports were not associated with FSIQ, SES, school status, and clinical manifestations of the disease. Neuropsychological tests were poorly related to parental reports of cognitive and behavioral difficulties. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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