Helicobacter Pylori Infection: Diagnostic Strategies in Primary Diagnosis and After Therapy.

Accurate diagnosis of Helicobacter pylori infection pre- and post-treatment is mandatory in the current era of decreasing prevalence and increasing antibiotic resistance. The diagnostic performance of most tests is poorer in clinical situations with low bacterial density which is seen in conditions...

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Publicado en:Digestive Diseases & Sciences Vol. 61; no. 1; pp. 19 - 25
Autores principales: Atkinson, Nathan, Braden, Barbara, Atkinson, Nathan S S
Formato: review Journal Article
Publicado: Springer Nature Jan2016
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2016
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      pub: Springer Nature
      place: New York, New York
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        atl: Helicobacter Pylori Infection: Diagnostic Strategies in Primary Diagnosis and After Therapy.
      aug:
        au:
          Atkinson, Nathan
          Braden, Barbara
          Atkinson, Nathan S S
        affil: Translational Gastroenterology Unit, Oxford University Hospitals NHS Trust, Headley Way Oxford OX3 9DU UK
      sug:
        subj:
          Helicobacter Infections Diagnosis
          Bacteriological Techniques
          Serologic Tests
          Breath Tests
          Endoscopy, Gastrointestinal
          Helicobacter Pylori
          Biopsy
          Predictive Value of Tests
          Helicobacter Pylori Drug Effects
          Helicobacter Pylori Immunology
          Immunoglobulins Blood
          Antibodies, Bacterial Blood
          Urease Analysis
          Helicobacter Infections Drug Therapy
          Antigens, Bacterial Analysis
          Bacterial Proteins Analysis
          Treatment Outcomes
          Helicobacter Infections Microbiology
          Feces Microbiology
          Scales
      ab: Accurate diagnosis of Helicobacter pylori infection pre- and post-treatment is mandatory in the current era of decreasing prevalence and increasing antibiotic resistance. The diagnostic performance of most tests is poorer in clinical situations with low bacterial density which is seen in conditions such as atrophic gastritis or intake of antisecretory and antibiotic medications. Noninvasive tests require less cost and resource but provide excellent accuracy; however, endoscopy with testing of gastric biopsy specimens is indicated where alarming symptoms are present or antibiotic susceptibility testing by culture is desired. Newer modalities such as polymerase chain reaction testing provide additional virulence and antibiotic sensitivity profiling. This article outlines new developments and the key parameters of each test, as careful selection of test modality within the clinical context is required for adequate management of infected symptomatic patients.
      pubtype: Academic Journal
      doctype:
        review
        Journal Article
      ougenre: Article
    language: English
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