Empathic accuracy and oxytocin after tryptophan depletion in adults at risk for depression.
Rationale: Major depressive disorder (MDD) has been associated with disturbances in social functioning and in the brain serotonin system. Reduced levels of serotonin may negatively influence social functioning, for example by impairing the recognition of facial emotion expressions. Objectives: The p...
| Publicado en: | Psychopharmacology Vol. 233; no. 1; pp. 111 - 121 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112063560&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112063560 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jan2016 vid: 233 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112063560 10.1007/s00213-015-4093-9 112063560 ppf: 111 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Empathic accuracy and oxytocin after tryptophan depletion in adults at risk for depression. aug: au: Hogenelst, Koen Schoevers, Robert Kema, Ido Sweep, Fred Rot, Marije affil: University Medical Center Groningen, Department of Psychiatry, University of Groningen, 9700 RB Groningen The Netherlands sug: ab: Rationale: Major depressive disorder (MDD) has been associated with disturbances in social functioning and in the brain serotonin system. Reduced levels of serotonin may negatively influence social functioning, for example by impairing the recognition of facial emotion expressions. Objectives: The present study investigated the effect of acute tryptophan depletion (ATD), which reduces brain serotonin, on a related component of social functioning, empathic accuracy (EA), and oxytocin levels. Methods: Individuals with (FH+) and without (FH−) a family history of MDD participated in a randomized, double-blind, crossover study. On two separate test days, participants ingested tryptophan-deficient and nutritionally balanced amino acid mixtures. Six hours later, they performed an EA task, which involved watching videos of people recounting autobiographical emotional events. While watching, participants continuously rated how these people felt during the recounting. Mood state was repeatedly assessed using the Positive Affect and Negative Affect Schedule and a series of visual analogue scales. Blood samples obtained at baseline and 5 h after mixture ingestion were assessed for tryptophan and oxytocin levels. Results: ATD decreased circulating levels of tryptophan and oxytocin. Nevertheless, there were no significant effects of ATD on EA or mood in either FH group. Conclusions: While previous studies have shown that acute reductions in brain serotonin alter the recognition of facial emotion expressions in never-depressed individuals, the present study suggests that empathic abilities may remain unaffected. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|