Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study.
Mild cognitive impairment in Parkinson's disease is associated with progression to dementia (Parkinson's disease dementia) in a majority of patients. Determining structural imaging biomarkers associated with prodromal Parkinson's disease dementia may allow for the earlier identification of those at...
| Publicado en: | Brain: A Journal of Neurology Vol. 138; no. 10; pp. 2974 - 2987 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
10/1/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112078528&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112078528 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00068950 2RY jtl: Brain: A Journal of Neurology issn: 00068950 maglogo: N pubinfo: dt: 10/1/2015 vid: 138 iid: 10 pid: 622 pub: Oxford University Press / USA artinfo: ui: 112078528 112078528 NLM26173861 112078528 10.1093/brain/awv211 NLM26173861 PMC4671477 112078528 ppf: 2974 ppct: 13 formats: tig: atl: Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study. aug: au: Mak, Elijah Li Su Williams, Guy B. Firbank, Michael J. Lawson, Rachael A. Yarnall, Alison J. Duncan, Gordon W. Owen, Adrian M. Khoo, Tien K. Brooks, David J. Rowe, James B. Barker, Roger A. Burn, David J. O'Brien, John T. Su, Li affil: Department of Psychiatry, University of Cambridge, UK sug: subj: Cognition Disorders Etiology Parkinson Disease Pathology Parkinson Disease Complications Gray Matter Pathology Female Aged, 80 and Over Adult Aged Neuropsychological Tests Nonparametric Statistics Middle Age Prospective Studies Magnetic Resonance Imaging Retrospective Design Severity of Illness Indices Brain Mapping Male Funding Source Human Aged, 80 & over Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Mild cognitive impairment in Parkinson's disease is associated with progression to dementia (Parkinson's disease dementia) in a majority of patients. Determining structural imaging biomarkers associated with prodromal Parkinson's disease dementia may allow for the earlier identification of those at risk, and allow for targeted disease modifying therapies. One hundred and five non-demented subjects with newly diagnosed idiopathic Parkinson's disease and 37 healthy matched controls had serial 3 T structural magnetic resonance imaging scans with clinical and neuropsychological assessments at baseline, which were repeated after 18 months. The Movement Disorder Society Task Force criteria were used to classify the Parkinson's disease subjects into Parkinson's disease with mild cognitive impairment (n = 39) and Parkinson's disease with no cognitive impairment (n = 66). Freesurfer image processing software was used to measure cortical thickness and subcortical volumes at baseline and follow-up. We compared regional percentage change of cortical thinning and subcortical atrophy over 18 months. At baseline, cases with Parkinson's disease with mild cognitive impairment demonstrated widespread cortical thinning relative to controls and atrophy of the nucleus accumbens compared to both controls and subjects with Parkinson's disease with no cognitive impairment. Regional cortical thickness at baseline was correlated with global cognition in the combined Parkinson's disease cohort. Over 18 months, patients with Parkinson's disease with mild cognitive impairment demonstrated more severe cortical thinning in frontal and temporo-parietal cortices, including hippocampal atrophy, relative to those with Parkinson's disease and no cognitive impairment and healthy controls, whereas subjects with Parkinson's disease and no cognitive impairment showed more severe frontal cortical thinning compared to healthy controls. At baseline, Parkinson's disease with no cognitive impairment converters showed bilateral temporal cortex thinning relative to the Parkinson's disease with no cognitive impairment stable subjects. Although loss of both cortical and subcortical volume occurs in non-demented Parkinson's disease, our longitudinal analyses revealed that Parkinson's disease with mild cognitive impairment shows more extensive atrophy and greater percentage of cortical thinning compared to Parkinson's disease with no cognitive impairment. In particular, an extension of cortical thinning in the temporo-parietal regions in addition to frontal atrophy could be a biomarker in therapeutic studies of mild cognitive impairment in Parkinson's disease for progression towards dementia. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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