Quantification of structural changes in the corpus callosumin children with profound hypoxic-ischaemic brain injury.
Background: Birth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules.Objective: To test the hypothesis that there is anatomically coherent regional volume loss of the corpus callosum as a result of this hemispheric abnormality.Mate...
| Published in: | Pediatric Radiology Vol. 46; no. 1; pp. 73 - 82 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112194871&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112194871 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Jan2016 vid: 46 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112194871 112194871 NLM26403618 112194871 10.1007/s00247-015-3444-3 NLM26403618 PMC4706576 112194871 ppf: 73 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Quantification of structural changes in the corpus callosumin children with profound hypoxic-ischaemic brain injury. aug: au: Stivaros, Stavros Radon, Mark Mileva, Reneta Connolly, Daniel Cowell, Patricia Hoggard, Nigel Wright, Neville Tang, Vivian Gledson, Ann Batty, Ruth Keane, John Griffiths, Paul Stivaros, Stavros M Radon, Mark R Connolly, Daniel J A Cowell, Patricia E Wright, Neville B Keane, John A Griffiths, Paul D affil: Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool UK sug: subj: Sensitivity and Specificity Magnetic Resonance Imaging Telencephalon Injuries Hypoxia-Ischemia, Brain Pathology Reproducibility of Results Reproducibility of Results Methods Telencephalon Sensitivity and Specificity Methods Magnetic Resonance Imaging Methods Hypoxia-Ischemia, Brain Telencephalon Pathology Funding Source Human Infant Female Male Adolescence Child Child, Preschool Infant: 1-23 months Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Background: Birth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules.Objective: To test the hypothesis that there is anatomically coherent regional volume loss of the corpus callosum as a result of this hemispheric abnormality.Materials and Methods: Study subjects included 13 children with proven acute profound hypoxic-ischaemic brain injury and 13 children with developmental delay but no brain abnormalities. A computerised system divided the corpus callosum into 100 segments, measuring each width. Principal component analysis grouped the widths into contiguous anatomical regions. We conducted analysis of variance of corpus callosum widths as well as support vector machine stratification into patient groups.Results: There was statistically significant narrowing of the mid-posterior body and genu of the corpus callosum in children with hypoxic-ischaemic brain injury. Support vector machine analysis yielded over 95% accuracy in patient group stratification using the corpus callosum centile widths.Conclusion: Focal volume loss is seen in the corpus callosum of children with hypoxic-ischaemic brain injury secondary to loss of commissural fibres arising in the paracentral lobules. Support vector machine stratification into the hypoxic-ischaemic brain injury group or the control group on the basis of corpus callosum width is highly accurate and points towards rapid clinical translation of this technique as a potential biomarker of hypoxic-ischaemic brain injury. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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