Assessment of renal allograft function early after transplantation with isotropic resolution diffusion tensor imaging.
Objectives: To investigate the value of diffusion tensor imaging (DTI) and tractography in renal allografts at the early stage after kidney transplantation.Methods: This study was approved by the institutional ethical review committee, and written informed consent was obtained. A total of 54 renal a...
| Publicado en: | European Radiology Vol. 26; no. 2; pp. 567 - 576 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112262172&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112262172 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2016 vid: 26 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112262172 112262172 NLM26017738 112262172 10.1007/s00330-015-3841-x NLM26017738 112262172 ppf: 567 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Assessment of renal allograft function early after transplantation with isotropic resolution diffusion tensor imaging. aug: au: Fan, Wen-jun Ren, Tao Li, Qiong Zuo, Pan-li Long, Miao-miao Mo, Chun-bai Chen, Li-hua Huang, Li-xiang Shen, Wen affil: Department of Radiology, Tianjin Medical University First Central Hospital, Tianjin 300192 China sug: subj: Kidney Physiopathology Magnetic Resonance Imaging Methods Kidney Transplantation Postoperative Complications Physiopathology Allografts Adult Young Adult Reproducibility of Results Male Adolescence Female Middle Age Human Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Male Female ab: Objectives: To investigate the value of diffusion tensor imaging (DTI) and tractography in renal allografts at the early stage after kidney transplantation.Methods: This study was approved by the institutional ethical review committee, and written informed consent was obtained. A total of 54 renal allograft recipients 2-3 weeks after transplantation and 26 age-matched healthy volunteers underwent renal DTI with a 3.0-T magnetic resonance imaging (MRI) system. Recipients were divided into three groups according to the estimated glomerular filtration rate (eGFR). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the cortex and medulla were measured and compared among the groups. Whole-kidney tractography was performed. Correlation of eGFR with diffusion parameters was evaluated.Results: In allografts with stable function, the medullary ADC was higher and the cortical FA was lower (p < 0.001) than in healthy kidneys. The cortical ADC, medullary ADC and FA decreased as the allograft function declined, and with a positive correlation with eGFR (p < 0.001); cortical FA did not. Tractography demonstrated a decrease of tract density in impaired functional allografts.Conclusions: Renal DTI produces reliable results to assess renal allograft function at the early stage after transplantation.Key Points: • DTI and tractography can evaluate renal allograft function at an early stage • Medullary FA, cortical and medullary ADC can effectively evaluate allograft function • Medullary FA, cortical and medullary ADC are correlated with eGFR in renal allografts • Medullary ADC increased and cortical FA decreased in stable allografts compared to control subjects • Medullary FA, cortical and medullary ADC decreased and allograft function declined. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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